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黄海洪

时间:2020/7/20 来源: 阅读:22219次


黄海洪

 

黄海洪 中国医学科学院药物研究所合成药物化学研究室研究员,博士生导师。中国医学科学院抗耐药结核创新药物研究重点实验室主任,第九届中国药学会抗生素专业委员会委员。长期以来从事抗耐药结核、抗炎免疫、代谢性疾病、抗肿瘤等治疗领域的创新药物研发工作,自2002年起先后主持承担两项国家科技部“863”计划课题、国家自然科学基金和北京市自然科学基金课题各一项、两项北京市科委创新药物临床前研究课题、四项国家新药创制科技重大专项课题、两项抗结核新药研发国际合作项目、多项企业委托新药研发项目,以及医科院医学与健康科技创新工程等课题,其中抗类风湿性关节炎1类新药盐酸氯苯哌酮、抗耐药结核1类新药吡法齐明已进入临床研究、抗耐药结核1类新药OTB-658、抗肿瘤1类新药AST-1601已递交临床试验申请。

 

联系方式:

E-mail: joyce@imm.ac.cn   Tel: 010-63165244

地址:北京市西城区南纬路甲2号,中国医学科学院药物研究所

邮编:100050

 

教育背景:

19859月-19897    北京师范大学化学系                    本科学士

19899月-19927    南开大学化学系有机化学专业      理学硕士

 

工作经历:

19928 - 20049    中国医学科学院药物研究所    实研、助研、副研

20049 - 至今           中国医学科学院药物研究所    研究员

20092 - 20102    美国特拉华大学化学与生物系  访问学者

 

专业研究领域:

抗耐药结核、抗炎免疫、代谢性疾病、抗肿瘤等治疗领域的创新药物研究,涉及药物分子设计与合成、活性天然产物的结构优化、新药研发项目的跨学科综合管理。

 

发表论文:

近年来以通讯联系人发表SCI论文三十余篇,代表性论文如下:

1Dongfeng Zhang#, Yu Lu#, Kai Liu, Binna Liu, Jingbin Wang, Gang Zhang, Hao Zhang, Yang Liu, Bin Wang, Meiqin Zheng, Lei Fu, Yanyan Hou, Ningbo Gong, Yang Lv, Chun Li, Christopher B. Cooper, Anna M. Upton, Dali Yin, Zhenkun Ma,* and Haihong Huang*. Identification of Less Lipophilic Riminophenazine Derivatives for the Treatment of Drug-Resistant Tuberculosis. J. Med. Chem., 2012, 55(19), 8409-8417.

2Chun Lin Zhang, Dong Feng Zhang, Hong Yi Zhao, Zi Yun Lin, Hai Hong Huang*. A facile protocol for N-Cbz protection of amines in PEG-600. Chinese Chemical Letters, 2012, 23, 789-792.

3LUO Can, TANG Ke, LI Yan, YIN DaLi, CHEN XiaoGuang* & HUANG HaiHong*. Design, Synthesis and in vitro Antitumor Evaluation of Novel Diaryl Urea Derivatives Bearing Sulfonamide Moiety. SCIENCE CHINA CHEMISTRY, 2013, 56(11), 1564-1572. 

4Gang Li, Jin Wang, Baokun Yuan, Dongfeng Zhang, Ziyun Lin, Peng Li, Haihong Huang*. Iron-catalyzed one-pot synthesis of benzimidazoles from 2-nitroanilines and benzylic alcohols. Tetrahedron Letters, 2013, 54(50), 6934-6936.

5Dongfeng Zhang, Peng Li, Ziyun Lin, Haihong Huang*. An Efficient and Convenient Protocol for Synthesis of 1,1-Difluoro-6-nitro-2,3-dihydro-1H-indene Derivatives. Synthesis, 2014, 46, 0613-0620.

6Chenshu Lu, Ke Tang, Yan Li, Peng Li, Ziyun Lin, Dali Yin, Xiaoguang Chen* and Haihong Huang*. Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents. Eur. J. Med. Chem., 2014, 77, 351-360.

7Gang Li, Li Li, Haihong Huang* and Dali Yin*. Ti (IV)-catalyzed cascade synthesis of tetrahydrofuro[3,2-d]oxazole from arene-1,4-diones. Org. Biomol. Chem.201513, 4418-4421.

8Peng Li, Xinwei Zhang, Yongqi Wu, Maosheng Cheng, Dongfeng Zhang, Gang Li, Ziyun Lin, Xiang Zhang*, Haihong Huang*. A facile and efficient synthesis of 4H-1,3-benzoxazine-4-one with electron-withdrawing group derivatives. Tetrahedron Letters, 2015, 56, 4683-4685.

9Gang Li#, Yi Huan#, Baokun Yuan, Jin Wang, Qian Jiang, Ziyun Lin, Zhufang Shen*, Haihong Huang*. Discovery of novel xanthine compounds targeting DPP-IV and GPR119 as anti-diabetic agents. Eur. J. Med. Chem., 2016, 124, 103-116.

10Hongyi Zhao, Yu Lu, Li Sheng, Zishuo Yuan, Bin Wang, Weiping Wang, Yan Li, Chen Ma, Xiaoliang Wang, Dongfeng Zhang,* and Haihong Huang*. Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis. ACS Med. Chem. Lett., 2017, 8, 533-537.

11Peng-Xu Wang, Ya-Nan Wang, Zi-Yun Lin, Gang Li*, and Hai-Hong Huang*. Facile and efficient synthesis of quinazoline-2,4(1H,3H)-diones through sequential hydrogenation condensation. Synthetic Communications, 2018, 48(10), 1183-1189.

12Meng Gao, Wenting Zhao, Hongyi Zhao, Ziyun Lin, Dongfeng Zhang* and Haihong Huang*. An efficient and facile access to highly functionalized pyrrole derivatives. Beilstein J. Org. Chem., 2018, 14, 884-890.

13Peng Li, Bin Wang, Xinwei Zhang, Sarah M. Batt, Gurdyal S. Besra, Tingting Zhang, Chen Ma, Dongfeng Zhang, Ziyun Lin, Gang Li*, Haihong Huang*, Yu Lu*. Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones. Eur. J. Med. Chem., 2018, 160, 157-170.

14Dongfeng Zhang, Yun Lin, Xi Chen, Wenting Zhao, Dongni Chen, Meng Gao, Qinglin Wang, Bin Wang, Haihong Huang*, Yongjun Lu*, and Yu Lu*. Docking- and Pharmacophore-Based Virtual Screening for the Identification of Novel Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (MptpB) Inhibitor with A Thiobarbiturate Scaffold. Bioorganic Chemistry, 2019, 85, 229-239.

15Peng Li, Yongqi Wu, Tingting Zhang, Chen Ma, Ziyun Lin, Gang Li* and Haihong Huang*. An efficient and concise access to 2-amino-4H-benzothiopyran-4-one derivatives. Beilstein J. Org. Chem., 2019, 15, 703–709.

16Keli Cui, Meng Gao, Hongyi Zhao, Dongfeng Zhang*, Hong Yan* and Haihong Huang*. An Efficient Synthesis of Aryl-Substituted Pyrroles by the Suzuki–Miyaura Coupling Reaction of SEM-Protected Pyrroles. Molecules, 2019, 24(8), 1594.

17Hui Chen, Peng Li, Rong Qin, Hong Yan, Gang Li*, Haihong Huang*. DMAP catalyzed one-pot synthesis of quinazoline-2,4-diones from 2-aminobenzamides and di-tert-butyl dicarbonate. ACS Omega, 2020, 5: 9614−9623.

18Yong-Qi Wu, Hai-Jia Lu, Wen-Ting Zhao, Hong-Yi Zhao, Zi-Yun Lin, Dong-Feng Zhang*, and Hai-Hong Huang*. A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide. Synthetic Communications, 2020, 50(6), 813–822.

19Hongyi Zhao, Wenting Zhao, Shihao Cheng, Haijia Lu, Dongfeng Zhang* and Haihong Huang*, Efficient and stereoselective one-pot synthesis of benzo[b]oxazolo[3,4-d][1,4]oxazin-1-ones. RSC Adv., 2020, 10, 24037.

20Gang Li#, Bingxu Meng#, Baokun Yuan, Yi Huan, Tian Zhou, Qian Jiang, Lei Lei, Li Sheng, Weiping Wang, Ningbo Gong, Yang Lu, Chen Ma, Yan Li, Zhufang Shen*, Haihong Huang*. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur. J. Med. Chem., 188(2020) 112017.

 

专利:

获得19项国内外专利授权。

 

 

 

 

 

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