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李莉

时间:2014/3/12 来源: 阅读:15894次


李莉

 

李莉 博士,研究员,硕士生导师。
 
联系方式:
电话:010-63165247(O)
传真:010-63165247
电子信箱:annaleelin@imm.ac.cn         
 
 
1997年毕业于北京师范大学化学系,获学士学位。2002年毕业于中国医学科学院放射医学研究所,获影像医学与核医学专业博士学位。2002年7月至2004年6月,在中国医学科学院药物研究所进行博士后研究工作。2004年7月至今在中国医学科学院药物研究所工作,先后任助理研究员、副研究员。参加了国家自然科学基金、国家科技攻关项目、科技部863项目、科技部SARS专项等课题的研究。
 
研究方向:手性光谱学在药学领域的基础与应用研究
研究内容:
1. 与新药发现有关的立体化学研究,包括:天然产物立体化学研究、手性药物结构修饰等。
2. 采用圆二色谱方法研究生物大分子与小分子(药物)的相互作用
 
近期发表的主要论文:
1)     Li Li, Qianqian Zhang, Bo Liu, Gang Liu. A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines. Molecules, 2013, 18, 5697-5705.
2)     Li Li*, Yan-Fei Liu*, Yi-Kang Si, De-Quan Yu. Chiroptical properties of Ajugol investigated by quantum chemical calculation using time-dependent density functional theory. Journal of Asian Natural Products Research, 2013, 15(6), 670-679. (*Co-first author.)
3)     Li Li, Chun Li, Yi-Kang Si, Da-Li Yin. Absolute configuration of Buagafuran: an experimental and theoretical electronic circular dichroism study. Chinese Chemical Letters, 2013, 24 (6), 500-502.
4)     Xiao-Jing Wang, Li Li, Shi-Shan Yu, Shuang-Gang Ma, Jing Qu, Yun-Bao Liu, Yong Li, Yadan Wang, Weibin Tang. Five new fawcettimine-related alkaloids from Lycopodium japonicum Thunb. Fitoterapia, 2013, 74-81.
5)     Xiao-Jing Wang, Li Li, Yi-Kang Si, Shi-Shan Yu, Shuang-Gang Ma, Xiu-Qi Bao, Dan Zhang, Jing Qu, Yun-Bao Liu, Yong Li. Nine new lycopodine-type alkaloids from Lycopodium japonicum Thunb. Tetrahedron, 2012, 68, 3288-3294.
6)     Ling Liu, Yan Li, Li Li, Ya Cao, Liangdong Guo, Gang Liu, and Yongsheng Che. Spiroketals of Pestalotiopsis fici Provide Evidence for a Biosynthetic Hypothesis Involving Diversified Diels–Alder Reaction Cascades. Journal of Organic Chemistry, 2013, 78 (7), 2922–3000.
7)     Li Li, Yi-Kang Si. Study on the absolute configurations of 3-alkylphthalides using TDDFT calculations of chiroptical properties. Chirality, 2012, 24(12): 987-993.
8)     Nan Zhao*, Li Li*, Jun-hong Liu, Peng-yu Zhuang, Shi-shan Yu, Shuang-gang Ma, Jing Qu, Nai-hong Chen, Li-jun Wu. New alkaloids from the seeds of Strychnos nux-vomica. Tetrahedron, 2012, 68, 3288-3294. (*Co-first author.)
9)     Xiang Zhang, Li Li*, Yi Kang Si, Da Li Yin. ECD spectrometric methods for detecting the enantioselective enzymatic hydrolysis of racemic 3-acetoxy- 4-phenyl-b-lactam. Chinese Chemical Letters, 2012, 23, 1197-1200.
10) Chuangjun Li, Li Li, Chao Wang, Jingzhi Yang, Fei Ye, Jinying Tian, Yikang Si, Dongming Zhang. A New Ursane-Type Nor-Triterpenoid from the Leaves of Eucommia ulmoides Oliv. Molecules, 2012, 17(12), 13960-13968.
11) Xiao-Jing Wang, Yun-Bao Liu, Li Li, Shi-Shan Yu,* Hai-Ning Lv, Shuang-Gang Ma, Xiu-Qi Bao, Dan Zhang, Jing Qu, and Yong Li. Lycojaponicumins D and E: Two New Alkaloids from Lycopodium japonicum. Organic Letters, 2012, 14 (22), 5688-5691.
12) Minghua Chen, Sheng Lin, Li Li, Chenggen Zhu, Xiaoliang Wang, Yanan Wang, Bingya Jiang, Sujuan Wang, Yuhuan Li, Jiandong Jiang, and Jiangong Shi. Enantiomers of an Indole Alkaloid Containing Unusual Dihydrothiopyran and 1,2,4-Thiadiazole Rings from the Root of Isatis indigotica. Organic Letters, 2012, 14 (22), 5668-5671.
13) Fan Zhang, Li Li, Shubin Niu, Yikang Si, Liangdong Guo, Xuejun Jiang, and Yongsheng Che. A Thiopyranchromenone and Other Chromone Derivatives from an Endolichenic Fungus, Preussia africana. Journal of Natural Products, 2012, 75(2): 230-237.
14) Gang Ding, Hailou Wan, Li Li, Amanda Juan Chen, Lin Chen, Hong Chen, Hongwu Zhang, Xinzhong Liu, Zhongmei Zou. Trichoderones A and B: Two Pentacyclic Cytochalasans from the Plant Endophytic Fungus Trichoderma gamsii. European Journal of Organic Chemistry, 2012, 2516-2519.
15) Fan Zhang, Gang Ding, Li Li, Xiaoyue Cai, Yikang Si, Liangdong Guo, Yongsheng Che. Isolation, antimicrobial activity, and absolute configuration of the furylidene tetronic acid core of pestalotic acids A–G. Organic & Biomolecular Chemistry, 2012, 10, 5307-5314.
16) Li Li, Yi-Kang Si. Study on the Absolute Configuration of Levetiracetam via Density Functional Theory Calculations of Electronic Circular Dichroism and Optical Rotatory Dispersion. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56: 465-470.
17) Jian Li, Li Li, Yikang Si, Xuejun Jiang, Liangdong Guo, and Yongsheng Che. Virgatolides A-C, Benzannulated Spiroketals from the Plant Endophytic Fungus Pestalotiopsis virgatula. Organic Letter, 2011, 13(10): 2670-2673.
 
 
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