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Haiyu Hu

Time:2017-5-24 Source: Read:1075


Haiyu Hu

 

Haiyu Hu, PhD. Prof.

Date of Birth: Nov. 11th, 1981.

Place of Birth: Liaoning Province, P. R. China.

Address: Institute of Materia Medica

1 Xian Nong Tan Street, Beijing, China,100050

Tel: +86 (0)10 6317-2589

E-mail: haiyu.hu@imm.ac.cn

 

Education Background:

Ph. D.                  2004.9-2009.6     Institute of Chemistry, Chinese Academy of Science.

B. S.                     2000.9-2004.6     Beijing Institute of Technology.

 

Research Experiences:

2015.03-present,    PI, Department of Synthetic Medicinal Chemistry,

                                Institute of Materia Medica, Chinese Academy of Medical Sciences &

                                Peking  Union Medical College;

2014.01-2015.02,    Junior PI, Department of Chemical Biology,

                                 Helmholtz Centre for Infection Research, Brunswick, Germany;

2010.09-2013.12,    Visiting scientist, R&D LGCR, Sanofi GmbH, Frankfurt, Germany;

                                Postdoc, Carsten Schultz Group, EMBL Heidelberg, Germany;

2009.07-2010.07,    Postdoc, Eiji Yashima Group, Nagoya University, Japan;

2004.09-2009.06,    Predoctoral Fellow, Chuan-Feng Chen Group, Institute of Chemistry,

                                Chinese Academy of Sciences (CAS), P. R. China.

 

Research Interests:

Our lab uses chemical, biochemical, and cell biological methods to develop novel imaging and therapy strategies. We develop new molecular probes and theranostic agents to enhance the diagnosis and treatment for cancer and bacterial infections, projects include:

1.      Enzyme activity-based in vivo imaging;

2.      Multi-Modal imaging agents;

3.      Small molecule-based drug delivery.

 

Selected Publications:

1.      Multivalent Siderophore DOTAM Conjugates as Theranostics for Imaging and Treatment of Bacterial Infections

Kevin Ferreira+, Hai-Yu Hu+, Verena Fetz+, Hans Prochnow, Bushra Rais, Peter P. Müller, Mark Brönstrup*, (+equally contributed)

 

Angew Chem Int Ed Engl. 2017, DOI: 10.1002/anie.201701358R1.

2.      Aminoglycoside-based Novel Probes for Bacterial Diagnostic and Therapeutic Applications

Qingyang Zhang, Qinghua Wang, Shengnan Xu, Limin Zuo, Xuefu You, Hai-Yu Hu*

 

Chem. Commun., 2017, 53, 1366-1369.

Selected as Front Cover

3.      In vivo visualization of osteoarthritic hypertrophic lesions

Hai-Yu Hu, Ngee-Han Lim, Hans-Paul Juretschke, Danping Ding-Pfennigdorff, Peter FlorianMarkus Kohlmann, Abdullah Kandira ,Jens Peter von Kries, Joachim Saas, Karl A. Rudolphi, K. Ulrich Wendt, Hideaki Nagase, Oliver Plettenburg, Marc Nazare*, Carsten Schultz*

 

Chemical Science, 2015, 11, 6256-6261.

4.      DOTAM Derivatives as Active Cartilage-Targeting Drug Carriers for the Treatment of Osteoarthritis.

Hai-Yu Hu+, Ngee-Han Lim+, Danping Ding-Pfennigdorff, Joachim Saas, K. Ulrich Wendt, Olaf Ritzeler, Hideaki Nagase, Oliver Plettenburg, Carsten Schultz*, Marc Nazare*,  (+equally contributed)

 

Bioconjugate Chem., 2015, 26, 383−388.

5.      In Vivo imaging of mouse tumors by a lipidated cathepsin s substrate.

Hai-Yu Hu+, Divya Vats+, Matej Vizovisek+, Lovro Kramer, Catherine Germanier, K. Ulrich Wendt, Markus Rudin, Boris Turk*, Oliver Plettenburg*, Carsten Schultz*, (+equally contributed)

 

 Angew Chem Int Ed Engl. 2014, 53, 7669-7673.

6.      Review: FRET-based and other fluorescent proteinase probes

Hai-Yu Hu+, Stefanie Gehrig+, Gregor Reither, Devaraj Subramanian, Marcus A. Mall, Oliver Plettenburg, Carsten Schultz*,

 

Biotechnol J. 2014, 9, 266-281.

 

 

 

 

 

 

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