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Liu AILIN

Time:2013/12/10 Source: Read:3584


Liu AILIN

Ailin Liu 刘艾林

Professor

 

Academic Qualifications

·         BSc, Xiamen University (Fujian province, China)

·         MSc, Nankai University (Tianjin, China)

·         PhD, University of Macau (Macau, China)

 

 


Teaching

M.Sc. and PhD Courses

1.     Experimental Pharmacology

2.     Drug Informatics

 


Research

Research Interests

·         Computational pharmacology, virtual drug screening, QSAR, data mining, drug informatics

·         Molecular pharmacology of Chinese medicines

·         Anti-influenza drug research

 


Selected Publications

 

1. Computational pharmacology

l  Gao L, Zu M, Wu S, Liu AL*, Du GH*. 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. Bioorganic & Medicinal Chemistry Letters, 2011, 21: 5964–5970.

l  Liu Y, Zhang L, Gong J, Fang H, Liu A, Du G, Xu W. Design, synthesis, and biological activity of thiazole derivatives as novel influenza neuraminidase inhibitors. J Enzyme Inhib Med Chem. 2011, 26(4):506-13.

l  Liu AL, Wang HD, Lee SM, Wang YT, Du GH. Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities. Bioorganic & Medicinal Chemistry, 2008, 16: 7141-7147.

l  Liu AL, Cao HP, Du GH. Drug Screening for Influenza Neuraminidase Inhibitors. Science in China Ser C, 2005, 48(1):1-5.

l  Liu AL, Guang HM, Zhu LY, Du GH, LEE SM Y, Wang YT. 3D-QSAR analysis of a new type of Acetylcholinesterase Inhibitors. Science in China Ser C, 2007, 50(6):726-30.

l  Zhang J, Wang Q, Fang H, Xu W, Liu A, Du G. Design, synthesis, inhibitory activity, and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors. Bioorg Med Chem. 2008; 16(7): 3839-47.

l  Zhang J, Xu W, Liu A, Du G. Design, synthesis, and preliminary evaluation of new pyrrolidine derivatives as neuraminidase inhibitors. Med Chem. 2008; 4(3): 206-9.

l  Zhang J, Wang Q, Fang H, Xu WF, Liu AL, Du GH. Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors. Bioorg. Med. Chem. 2007, 15, 8286–8294.

 

2. Influenza virus and traditional Chinese medicines

l  Zu M, Yang F, Zhou W, Liu A*, Du G*, Zheng L*. In vitro anti-influenza virus and anti-inflammatory activities of theaflavin derivatives. Antiviral Res. 2012, 94: 217-224 (SCI: 4.439).

l   Yang F, Zhou WL, Liu AL*, Qin HL, Lee SM, Wang YT, Du GH*. The Protective Effect of 3-Deoxysappanchalcone on In Vitro Influenza Virus-induced Apoptosis and Inflammation. Planta Med. 2012, 78:968-973. (SCI2.369)

l  Zhan P, Wang L, Liu H, Chen X, Li X, Jiang X, Zhang Q, Liu X, Pannecouque C, Naesens L, De Clercq E, Liu A, Du G. Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents. Arch Pharm Res. 2012, 35(6):975-86. (SCI IF=1.592)

l  Liu B, Deng AJ, Yu JQ, Liu AL, Du GH, Qin HL. Chemical constituents of the whole plant of Elsholtzia rugulosa. J Asian Nat Prod Res. 2012, 14(2):89-96.

l  Li Z, Zhan P, Naesens L, Vanderlinden E, Liu A, Du G, De Clercq E, Liu X. Synthesis and Preliminary Biologic Evaluation of 5-Substituted-2-(4-substituted phenyl)-1,3-Benzoxazoles as A Novel Class of Influenza Virus A Inhibitors.  Chem Biol Drug Des. 2012, 79(6):1018-24.

l  Liu AL, Yang F, Zu M, Zhou D, Lee SM, Wang YT, Du GH. In Vitro anti-influenza viral activities of stilbenoids from the Lianas of Gnetum pendulum. Planta Med, 2010, 76: 1874-1876.

l  Yu M, Liu A, Du G, Naesens L, Vanderlinden E, De Clercq E, Liu X. Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents. Chem Biol Drug Des. 2011, 78(4):596-602.

l  Zhang L, Cheng YX, Liu AL, Wang HD, Wang YL, Du GH. Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa. Molecules. 2010, 15(11): 8507-8517.

l  Liu AL, Shu SH, Qin HL, Lee SM, Wang YT, Du GH. In vitro anti-influenza viral activities of constituents from Caesalpinia sappan. Planta Medica, 2009, 75(4): 337-339.

l  Liu AL, Liu B, Qin HL, Lee SM, Wang YTDu GH. Anti-influenza Virus Activities of Flavonoids from the Medicinal Plant Elsholtzia rugulosa. Planta Medica, 2008, 74: 746-51.

l  Liu AL, Wang, YT, Du, GH. Neuraminidase as a target for drugs for the treatment of influenza. Drugs Fut 2005, 30(8): 799-806.

l  Liu AL, Lee SMY, Wang YT, Du GH. Elsholtzia: Review of Traditional Uses, Chemistry and Pharmacology. Journal of Chinese Pharmaceutical Sciences, 2007, 16(2):73-8.

l  Wang P, Liu AL, Li ZH, Du GH, Qin HL. Stemoninine-type alkaloids from the roots of Stemona sessilifolia.J Asian Nat Prod Res. 2008; 10(4): 311-4.

l  Wang P, Liu AL, An Z, Li ZH, Du GH, Qin HL. Novel alkaloids from the roots of stemona sessilifolia. Chemistry & Biodiversity, 2007, 4:523-30.

l  Liu A, Cao H, Du G. Drug screening for influenza neuraminidase inhibitors. Sci China C Life Sci. 2005, 48(1):1-5.

l  Liu AL* and Du GH. Antiviral Properties of Phytochemicals. Patra A.K. (ed.) Dietary Phytochemicals and Microbes. 93-126, DOI: 10.1007/978-94-007-3926-0_3, Springer sciences, Business Media Dordrecht, 2012.

 

3. Others

l  Lam In Kei, Alex Deepa, Wang You-Hua, Liu Ping, Liu Ai-Lin, Du Guan-Hua  and Lee Simon MingYuen. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel anti-angiogenesis agent. Molecular Nutrition and Food Research, 2012 56(6):945-56 (IF=4.301)

l  Huang F, Li S, Lu X, Liu A, Du G, Shi G. Two glutathione S-transferase inhibitors from Radix Angelicae sinensis. Phytother Res. 2011, 25(2):284-9.

l  Liu R, Meng F, Zhang L, Liu A, Qin H, Lan X, Li L, Du G. Luteolin isolated from the medicinal plant Elsholtzia rugulosa (Labiatae) prevents copper-mediated toxicity in β-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells. Molecules. 2011, 16(3):2084-96.

l  Gong LL, Fang LH, Peng JH, Liu AL, Du GH. Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors. J Biotechnol. 2010, 145(3):295-303.

l  Liu AL, Lee SM, Wang YT, Du GH. Progress on active substances from Salvia miltiorrhiza.  Chinese Journal of Pharmaceuticals, 2007, 42: 641-6.

l  Zhou Y, Liu A, Wang W, Du G. Using the protein chip to screen agonists and antagonists of the androgen receptor. J Biomol Screen. 2008; 13(4): 276-84.

l  Wu L, Liu AL, Lu Y, Du GH. 2,7-Diacetyxanthene. Acta Crystallographica E. 2006. E62:o1770-1.

 

Research Projects

·         Drug factors analysis of major diseases clinical effect, funded by Health industry research projects, subproject, No. 200802041, 2008-2011.

·          The establishment of a new target RNA polymerase activity assay for ani-influenza, funded by Beijing Natural Science Foundation, No. 7103172, 2010-2011.

·         New Drug information technology platform - research and development of new drugs policy library construction, funded by Key New Drug Creation major science and technology project, subproject, No. 2009ZX09309-001, 2009-2010.

·         Shijiazhuang Pharmaceutical Group innovative drug discovery research alliance building: Shijiazhuang Pharmaceutical Group - Institute of Materia Medica of the Chinese Academy of Medical Sciences Demonstration Laboratory, funded by Key New Drug Creation major science and technology project, subproject, No. 2008ZX09401-004, 2008-2010.

·         Innovative drug research and development technology platform – high-efficency screening of chemical drugs, funded by Key New Drug Creation major science and technology project, subproject, No. 2009ZX09301-003-2-1, 2009-2010.

·         The construction of innovation drug screening system and a new technology platform, funded by Key New Drug Creation major science and technology project, subproject, No. 2009ZX09302-003, 2009-2010.

·         Re-evaluation of the anti-influenza clinical drug, funded by National Technology Support Program, subproject, 2009-2010.

·         Medical and health science data sharing network - Pharmacy science data center, funded by National Science and Technology Infrastructure construction projects, subproject, No. 2005DKA32406, 2005-2009.

·         The establishment of drug targets database, funded by National Science and Technology Infrastructure project, No. 2003DIB1J085, 2003-2005.

·         Research and application of innovative drug screening technology platform, funded by 863 plan “major projects for innovative drug and modernization of traditional Chinese medicines”, subproject, No. 2002AA2Z242B and 2004AA2Z3782, 2002 – 2006.

·         Design, synthesis and activity evaluation of new type of neuraminidase inhibitors, funded by Central nonprofit research institutes fundamental research projects, No. 2007ZD01, 2008-2010.

·         Natural lead discovery of influenza virus endon uclease PA inhibitor and its target validation study, funded by Active substances of natural medicine and the function of the State Key Laboratory, 2012-2016

 

Community Service

·         Reviewer of national publications, such as Acta Pharmaceutica Sinica, Chinese Pharmaceutial Journal, China Journal of Chinese Materia Medica, and so on.

·         Review of some internationall publications, such as Biotechnology and Bioprocess Engineering, Journal of Asian Natural Products Research, Science in China, and so on.

·         An evaluation expert of Doctoral Fund of the Ministry of Education, Beijing Natural Science Foundation, Natural Science Foundation of Zhejing Province, and so on.

 

Awards and Honors

·         Du GH, Liu AL, et al. Evaluation of bioactive natural products. Third prize of Chinese Medical Science and Technology Award, Feb 2011.

·         Du GH, Zhou Y, Zhang TT, Liu AL, et al. Research and application of new type of protein chip technology used for high-throughput drug screening. Second prize of Beijing Science and Technology Award, Feb 2009.

·         Du GH, Wang XL, Hu JJ, Liu AL, et al. Research and application of high-throughput drug screening technology system. Second prize of Beijing Science and Technology Award, Dec 2002.

·         Du GH, Wang XL, Hu JJ, Liu AL, et al. Research and application of high-throughput drug screening technology system. Third prize of Chinese Medical Science and Technology Award, Dec 2002.

·         Gao L, Fang JS, Zhou D, Wang YT, Liu AL*, Du GH*. In silico target fishing for the potential targets and molecular mechanisms of baicalein as an anti-parkinsonian agent. The 2nd World Conference on the Pharmacology of Natural and Chinese Medicines, Nov 2-6, 2012, Macau. (Excellent poster presentation award)

 

 


Contact Details

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College

1 Xian Nong Tan Street, Xicheng District, Beijing 100050, China

Telephone: +86-10-83150885

Fax: +86-10-63165184

E-mail: liuailin@imm.ac.cn

 

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