Targeting TRIB3 to turn up the temperature on cold tumors
Colorectal cancer (CRC) ranks as the third most prevalent malignant tumor worldwide. Surgery, chemotherapy and radiotherapy have been the first choice for treatment of CRC for a long time. Therapeutic targeting of immune checkpoint molecules has generated substantial excitement for the treatment of several solid tumors such as melanoma and lung cancer. However, for CRC, only about 15% patients benefit from immune checkpoint blockade (ICB) treatment. The lack of CD8+ T cell infiltration, defining...
Professor Haihong Huang's Group Making New Progress on Discovery of Anti-DR TB Drugs
Drug-Resistant Tuberculosis (DR-TB) is a major contagious disease which seriously threatens the human health. It is significantly meaningful to develop novel anti-DR TB drugs with new mechanisms of action.
Prof. Huang’s group has been dedicating in the research of novel anti-DR TB drugs since 2007. Recently, collaborated with Dr. Gurdyal S. Besra’s Group in University of Birmingham (UOB), a series of novel thiophene-arylamide derivatives targeting DprE1 which is crucial for mycobacterial cell...
Zeper Abliz and Jiuming He's team developed a spatial metabolomics to map the metabolic networks in rat brain by using mass spectrometry imaging
The brain is one of the most complicated structured and functional organs, the signal transduction and communication of the brain metabolic network is the important molecular mechanism and functional basis, which is of great significance for the function study of the central nervous system,the pathogenesis explanation of mental diseases as well as the drug development. However, it is challenging for the characterization of metabolic networks as well as molecular recognition in the brain due to t...
The clinical results of Mulberry Twig Alkaloids Tablet were published in Diabetes Care
On April 9, 2021, the results of a phase IIIa Trial of the Mulberry Twig Alkaloids Tablet, an original natural hypoglycemic drug, were published in Diabetes Care. This article, entitled“Efficacy and Safety of Mulberry Twig Alkaloids Tablet for Treatment of Patients with Type 2 Diabetes: A Multicenter, Randomized, Double-Blind, Double-Dummy and Parallel Controlled Clinical Trial”, was co-authored by Peking Union Medical College Hospital, the Institute of Materia Medica of Chinese Academy of Medic...
Professor Jian-Dong Jiang / Professor Yan Wang of Institute of Materia Medica and Academician Xuetao Cao of Institute of Basic Medical Sciences jointly reveal that berberine improves Parkinson's disease through the gut microbiota
February 24, 2021, Professor Jian-Dong Jiang and Professor Yan Wang from State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, and Academician Xuetao Cao from Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, jointly published a paper online in Signal Transduction and Targeted Therapy titled "Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota" as co-corresp...
Innovative progress in the research of the infection mechanism of coronaviruses
The Tan lab at the Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical college recently carried out an exploratory research into the infection mechanism of coronaviruses from an innovative perspective, i.e., by systematically comparing the binding of the SARS-CoV, MERS-CoV, SARS-CoV-2 S protein subunits, full-length molecules and their trimers to different heparan sulfate (HS) structures and oligosaccharides, through the collaboration with the Cui lab at the...
New findings on the self-resistance mechanism in the biosynthesis of macrolide antibiotics
Youcai Hu's group in the State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, has revealed a completely new type of self-resistance mechanism in the biosynthesis of a fungal macrolide antibiotic involving a cycle of extracellular oxidative activation and intracellular reductive inactivation. This work entitled “Self-Resistance in the Biosynthesis of Fungal Macrolides Involvi...
The Hu Haiyu/Lei Xiaoguang research group developed a new technology for accurate diagnosis of bacterial infections based on the Trojan hors
Bacterial resistance caused by the abuse of antimicrobial drugs has been a global crisis. There is an urgent need to develop rapid and sensitive diagnostic methods to detect pathogenic bacteria in clinical samples. Bacterial infection-specific molecular probes combined with medical molecular imaging technology provide new ideas for rapid and accurate diagnosis of bacterial infections in vivo and in vitro. However, molecular probes and imaging methods that can label pathogens with high specificit...
New progress in the chemo-enzymatic synthesis of antidiabetic C- glycosides made by groups of Jungui Dai and Fei Ye from Institute of Materi
A paper entitled "Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides" was published online in Nature Communications on October 14, 2020. The research leading by Prof. Jungui Dai from the State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, cooperated with Prof. Fei Ye from Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study repo...
Zhuowei Hu's laboratory identified a novel therapeutic target for non-small-cell lung cancer
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are first-line therapy for NSCLC. However, patients eventually deteriorate after inevitable acquisition of EGFR TKI-resistant mutations, which limits the long-term efficacy of EGFR-TKIs. Moreover, the majority of lung cancer patients who harboring wild-type EGFR achieve relatively little benefit from EGFR TKIs. Elevated wild-type EGFR expression not only participates in the pathogenesis and progression of lung cancer but als...