LI Li
Principal Investigator
Work experience
09/2014 – present: Professor, IMM, CAMS & PUMC
09/2007 – 08/2014: Associate professor, IMM, CAMS & PUMC
07/2004 – 08/2007: Assistant professor, IMM, CAMS & PUMC
07/2002 – 06/2004: Post-doctoral fellow, IMM, CAMS & PUMC
Research field
1. Research and application of chiroptical spectroscopy, including the stereochemical analysis of chiral drugs and natural products, chiral resolution, and chiral sensing, etc.
2. Design and synthesis of novel drugs, focusing on anticancer and anti-neurodegeneration diseases.
1. Regioselectivity of aminomethylation in 3-acetyl-7-hydroxycoumarins: Mannich bases and Betti bases. New Journal of Chemistry , 2021, 45, 9864 - 9871.
2. Specific Optical Rotation and Absolute Configuration of Flexible Molecules Containing a 2-Methylbutyl Residue. European Journal of Organic Chemistry , 2020, 30, 4768-4774.
3. A Rapid and Sensitive Method for Chiroptical Sensing of a-Amino Acids via Click-like Labeling with o-Phthaladehyde and p-Toluenethiol. Chemical Science , 2021, 12, 2504-2508.
4. Ultrasound-promoted specific chiroptical sensing of cysteine in aqueous solution and cells. Microchemical Journal , 2020, 153, 104471.
5. Isolation and characterization of cytotoxic withanolides from the calyx of Physalis alkekengi L. var franchetii . Bioorganic Chemistry , 2020, 96, 103614.
6. Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease. European Journal of Medicinal Chemistry , 2019, 173, 203-212.
7. Cytotoxic Withanolides from the Whole Herb of Physalis angulata L. Molecules , 2019, 24(4), 1608.
8. Chiral resolution, absolute configuration determination, and stereo-activity relationship study of the IDO1 inhibitor NLG919. Tetrahedron , 2018, 74 (24), 3045-3051.
9. Alashinol H, an epoxylignan with an unusual six-membered cyclic hemiacetal from Syringa pinnatifolia. Tetrahedron Letters , 2018, 59, 1356-1359.
10. Lignans and isoflavonoids from the stems of Pisonia umbellifera . RSC Advances , 2018, 8, 16383-16391.
11. Enantioseparation, stereochemical assignment and chiral recognition mechanism of sulfoxide-containing drugs. Molecules , 2018, 23(10), 2680.
12. Ring-locking strategy facilitating determination of absolute optical purity of 2-amino-1-butanol by reverse-phase high-performance liquid chromatography. RSC Advances , 2017, 7, 45714-45720.
13. A high-performance liquid chromatography-electronic circular dichroism online method for assessing the absolute enantiomeric excess and conversion ratio of asymmetric reactions. Scientific Reports , 2017, 7: 43278.
14. Improved synthesis of unnatural amino acids for peptide stapling. Tetrahedron Letters , 2017, 58(24): 2374–2377.
15. Azacyclo-indoles and Phenolics from the Flowers of Juglans regia . Journal of Natural Products , 2017, 80, 2189-2198.
16. Six scalemic mixtures of 6-monosubstituted dihydrobenzophenanthridine alkaloids from Chelidonium majus and optically active structures of enantiomers. Phytochemistry , 2017, 14, 159-170.
17. Decalin-Containing Tetramic acids and 4-hydroxy-2-pyridones with Antimicrobial and Cytotoxic Activity from the Fungus Coniochaeta cephalothecoides Collected in Tibetan Plateau (Medog). Journal of Organic Chemistry , 2017, 82, 11474-11486.
