抗炎免疫药理学；主要研究方向：
（1）髓系细胞如树突状细胞的发育与功能的分子调控机制；
（2）髓系细胞在肿瘤及自身免疫性疾病中的作用机理及新药靶点发现；
（3）新型药物靶向递送系统的研究与应用。

1. Gaona Shi, Yu Zhou, Wenshuai Liu, Chengjuan Chen, Yazi Wei, Xinlong Yan, Lei Wu, Weiwei Wang*, Lan Sun*, Tiantai Zhang*, Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A2A/2B receptors in tolerogenic dendritic cells. Acta Pharm. Sin. B 2023;13(6):2778-2794.
2. Xiang Wang, Gaona Shi, Shengnan Xu, Yuansheng Sun, Hailin Qiu, Qinghua Wang, Xiaowan Han, Qingyang Zhang*, Tiantai Zhang*, Hai-Yu Hu*. Unravelling Immune-Inflammatory Responses and Lysosomal Adaptation: Insights from Two-Photon Excited Delayed Fluorescence Imaging. Adv Healthc Mater. 2024;13(15):e2304223.
3. Xiang Wang‡, Gaona Shi‡, Rao Wei, Meng Li, Qingyang Zhang, Tiantai Zhang*, Chuan-Feng Chen* and Hai-Yu Hu*. Fine-tuning of stable organic free-radical photosensitizers for photodynamic immunotherapy. Chem. Sci. 2024,15,6421-6431.
4. Gao-Na Shi, Min Hu, Chengjuan Chen, Junmin Fu, Shuai Shao, Yu Zhou, Lei Wu, Tiantai Zhang*. Methotrexate enhances antigen presentation and maturation of tumour antigen loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine. Ther. Adv. Med. Oncol., 2021,13:1-16.
5. Shi Gao-Na, Zhang Chuang-Nian#, Xu Rong, Niu Jin-Feng, Song Hui-Juan, Zhang Xiu-Yuan, Wang Wei-Wei, Wang Yan-Ming, Li Chen*, Wei Xiao-Qing*, Kong De-Ling*. Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine. Biomaterials, 2017,113(1): 191-202.
6. Hui Yang#, Gaona Shi#, Chen Ge#, Jie Huang#, Lingfei Wan, Zhaohai Wang, Yunhui Liu, Runqing Jia, Minglian Wang, Liming Zhang, Zhijun Zhang, Xinlong Yan. Functionalized graphene oxide as a nanocarrier for multiple suppressive miRNAs to inhibit human intrahepatic cholangiocarcinoma. Nano Select.2021;1-13.
7. Zhang Chuangnian#, Shi Gaona#, Zhang Ju, Song Huijuan, Niu Jinfeng, Shi Shengbin, Huang Pingsheng, Wang Yanming, Wang Weiwei, Li Chen*, Kong Deling*. Targeted antigen delivery to dendritic cell via functionalized alginate nanoparticles for cancer immunotherapy. J. Control. Release, 2017,256(6):170-181.
8. Shi Gao-na, Liu Yan-li, Lin Hai-ming, Yang Shi-lin, Feng Yu-lin, Reid Paul F., Qin Zheng-hong*. Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin, Acta Pharmacol. Sin., 2011, 32(10):1233-1238.