1. 创新药物的研究与开发
以具有强生物活性的天然产物为结构先导物，利用全合成手段，设计、合成具有生物活性的结构类似物，以期能够发现具有自主知识产权的创新药物。
2. 生物活性天然产物全合成
致力于建立高效的天然产物全合成方法，解决天然产物来源，为后续结构改造奠定基础。
3. 有机合成方法学研究
开发高效的有机化学合成新方法，包括基于苯炔化学构建药物化学常见骨架、使用有机小分子实现常见有机反应的不对称催化等。

1. Weilun Cao, Junmin Dong, Xuan Pan*, Zhanzhu Liu*, Straightforward Access to the Dispirocyclic Framework via Regioselective Intramolecular Michael Addition, Molecules, 2025, 30(15), 3164.
2. Xiaohui Geng1, Cunyu Feng1, Xuan Pan*, Yi Huan*, Zhanzhu Liu*, Collective Synthesis and PCSK9 Inhibitory Activities of Pavine and Isopavine Alkaloids, Journal of Natural Products, 2025, 88(7), 1828-1839.
3. Zeyu Tao1, Jichen Guan1, Guangyan Zhang, Junyi Liu, Xuan Pan*, Fangfang Lai* and Zhanzhu Liu*, Total synthesis and SARS-CoV-2 3CLpro inhibition activities of (±)-tuaimenal A and its derivatives, Journal of Natural Products, 2025, 88(6), 1349-1359.
4. Xuan Pan, Tao Sheng, Zhanzhu Liu*, A concise total synthesis of monoterpenoid indole alkaloid (-)-voacafricine A, Chinese Chemical Letters, 2025, 36(10), 110913-110917.
5. Guangyan Zhang, Beibei Yang, Li Li, Xuan Pan*, Zhanzhu Liu*, Total Synthesis of Artapilosine A and Artapilosine B, Journal of Natural Products, 2024, 87(12), 2863-2871.
6. Caiyun Ma1, Rao Wei1, Rui Yu, Ling Lei, Xuan Pan*, Hai-Yu Hu**, Bo Feng***, Zhanzhu Liu ****, Design, synthesis of griseofamine A derivatives and development of potent antibacterial agents against MRSA, European Journal of Medicinal Chemistry, 2024, 276, 116703.
7. Tao Sheng, Caiyun Ma, Guangyan Zhang, Xuan Pan*, Zhanzhu Liu*, Asymmetric total synthesis of griseofamine B and its three stereoisomers, Journal of Natural Products, 2022, 85(4), 1128-1133.
8. Xuan Pan‡, Rui Yu‡, Zhanzhu Liu*, An improved total synthesis of griseofamine A, Tetrahedron Letters, 2021, 67, 152894-152895.
9. Yantao Ma, Xuan Pan*, Baohe Guan, Guangyan Zhang, Zhanzhu Liu*, Synthesis and cytotoxicity of (−)-homorenieramycin G and its derivatives, Organic & Biomolecular Chemistry, 2020, 18, 9883-9894.
10. Xuan Pan, Zhanzhu Liu*, Total synthesis and antibacterial activity evaluation of griseofamine A and 16-epi-griseofamine A, Organic Letters, 2019, 21(7), 2393-2396.
11. Yi Huan‡, Xuan Pan‡, Jun Peng, Chunming Jia, Sujuan Sun, Guoliang Bai, Xing Wang, Tian Zhou, Rongcui Li, Shuainan Liu, Caina Li, Quan Liu, Zhanzhu Liu*, Zhufang Shen*, A novel specific peroxisome proliferator-activated receptor γ (PPARγ) modulator YR4-42 ameliorates hyperglycaemia and dyslipidaemia and hepatic steatosis in diet-induced obese mice, Diabetes Obesity and Metabolism, 2019, 2553-2563.
12. Xuan Pan, Zhanzhu Liu*, Synthesis of 3-aryl-3-benzazepines via aryne [1,2] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines, Organic Chemistry Frontiers, 2018, 5(11), 1798-1810.
13. Xuan Pan‡, Yantao Ma‡, Zhanzhu Liu*, A concise synthesis of (E)-3-aryl-2,3,4,5-tetrahydro-1H-3-benzazonines by aryne induced [2,3] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines, Organic & Biomolecular Chemistry, 2018, 16(40), 7393-7399.
14. Xuan Pan‡, Lulu Tao‡, Ming Ji, Xiaoguang Chen, Zhanzhu Liu*, Synthesis and cytotoxicity of novel imidazo[4,5-d]azepine compounds derived from marine natural product ceratamine A, Bioorganic & Medicinal Chemistry Letters, 2018, 28(5), 866-868.
15. Lulu Tao, Xuan Pan**, Ming Ji, Xiaoguang Chen, Zhanzhu Liu*, Effective synthesis and cytotoxicity of novel microtubule-stabilizing agent ceratamine A analogues, Tetrahedron, 2017, 73(15), 2159-2171.
16. Xuan Pan, Yi Huan, Zhufang Shen, Zhanzhu Liu*, Synthesis and biological evaluation of novel tetrahydroisoquinoline-C-aryl glucosides as SGLT2 inhibitors for the treatment of type 2 diabetes, European Journal of Medicinal Chemistry, 2016, 114, 89-100.
17. Xuan Pan, Ke Wang, Baohe Guan, Zhanzhu Liu*, Synthesis of indolo[2,3-a]pyrrolo[3,4-c]carbazoles via the oxidative cyclization of bisindolylmaleimides with Pd(TFA)2/Cu(OAc)2, Journal of Heterocyclic Chemistry, 2015, 52, 911-913.