活性天然产物的发现、结构优化及新药研究。

1. Yingda Zang#, Haijie Wu#, Xinyi Chen#, Zhiling Ma, Chuangjun Li, Jie Ma, Xiaoguang Chen, Li Sheng*, Sen Zhang*, Dongming Zhang*, Synthesis and biological evaluation of novel Psidium meroterpenoid derivatives against cisplatin-induced acute kidney injury. J Med Chem, 2024, 67 (16), 14234-14255.
2. Xinyi Chen#, Jichen Guan#, Yuzhi Lin, Haowen Luo, Junyi Liu, Jie Ma, Chuangjun Li, Dongming Zhang*, Yingda Zang*, Fangfang Lai*, Design and synthesis of novel sulfur-substituted triptolide with the ability to induce autophagy through inhibition of SRSF1 expression, European Journal of Medicinal Chemistry, 2025, 287, 117342.
3. Yingda Zang#, Lei Huang#, Xinyi Chen#, Chuangjun Li, Jie Ma, Xiaoguang Chen, Dongming Zhang*, Fangfang Lai*, Novel nitric oxide-releasing derivatives of pyranocarbazole as antitumor agents: Design, synthesis, biological evaluation, and nitric oxide release studies, European Journal of Medicinal Chemistry, 2022, 244, 114832.
4. Yingda Zang#, Jingwen Ning#, Ke Liu, Meiyu Shang, Caixia Zang, Chuangjun Li, Jie Ma, Xinyi Chen, Jingwei Ma, Gen Li, Yang Yang, Xiuqi Bao, Dan Zhang*, Dongming Zhang*, Design, synthesis and biological evaluation of pyranocarbazole derivatives against Alzheimer’s disease, with antioxidant, neuroprotective and cognition enhancing properties, Bioorganic Chemistry, 2022, 129, 106179.
5. Yingda Zang#, Fangfang Lai#, Junmin Fu, Chuangjun Li, Jie Ma, Chengjuan Chen, Ke Liu, Tiantai Zhang, Xiaoguang Chen*, Dongming Zhang*, Novel nitric oxide-releasing derivatives of triptolide as antitumor and anti-inflflammatory agents: design, synthesis, biological evaluation, and nitric oxide release studies, European Journal of Medicinal Chemistry, 2020, 190, 112079.
6. Yingda Zang#, Xiuyun Song#, Chuangjun Li, Jie Ma, Shifeng Chu, Dandan Liu, Qian Ren,Yan Li, Naihong Chen*, Dongming Zhang*, Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo, European Journal of Medicinal Chemistry, 2018, 143, 438-448.
7. Yingda Zang#, Caixia Zang#, Jinying Tian, Kailing Xu, Chuan Li, Chuangjun Li, Yang Yang, Fei Ye, Dan Zhang, Dongming Zhang*, Jie Ma*, Chiral separation and bioactivities of six pairs of enantiomeric dilignans from Magnolia officinalis var. Biloba, Phytochemistry, 2024, 219, 113964.
8. Haijie Wu#, Xiaohu Shi#, Yingda Zang#, Xiaodi Zhao, Xikun Liu, Weida Wang, Wenying Shi, Clarence T.T. Wong, Li Sheng*, Xiaoguang Chen *, Sen Zhang*, 7-hydroxycoumarin-β-D-glucuronide protects against cisplatin-induced acute kidney injury via inhibiting p38 MAPK-mediated apoptosis in mice, Life Sciences, 2023, 327 121864.
9. Junmin Fu#, Yingda Zang#, Yu Zhou, Chengjuan Chen, Shuai Shao, Gaona Shi, Lei Wu, Guoyuan Zhu, Tao Sun*, Dongming Zhang*, Tiantai Zhang*, Exploring a novel triptolide derivative possess anti-colitis effect via regulating T cell differentiation, International Immunopharmacology, 2021, 94, 107472.
10. Ke Liu#, Yingda Zang#, Cangjie Shen, Chuangjun Li, Jie Ma, Jingzhi Yang, Xingyan Sun, Xinyi Chen, Nan Wang, Dongming Zhang*, Synthesis and biological evaluation of pyranocarbazole derivatives as anti-tumor agents, Bioorganic & Medicinal Chemistry Letters, 2021, 33, 127739.
11. Xinyi Chen#, Yingda Zang#, Sen Zhang, Haijie Wu, Jie Ma, Xiaoguang Chen, Chuangjun Li*, Dongming Zhang*, Psidials L and M and Psipinene, three novel meroterpenoids with significant protective activity toward cisplatin-damaged HK2 cells from the leaves of Psidium guajava, Tetrahedron Letters, 2023, 124, 154575.