神经退行性疾病的发病机制研究和新药研发

1. Han QT#, Yang WQ#, Zang CX#, Zhou L#, Zhang CJ, Bao X, Cai J, Li F, Shi Q, Wang XL, Qu J, Zhang D, Yu SS. The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin. Signal Transduct Target Ther. 2023, 8: 101.
2. Zang CX, Liu H, Ning J, Chen Q, Jiang Y, Shang M, Yang Y, Ma J, Dong Y, Wang J, Li F, Bao X, Zhang D. Emerging role and mechanism of HACE1 in the pathogenesis of neurodegenerative diseases: A promising target. Biomed Pharmacother. 2024, 172: 116204.
3. Pang QQ#, Zang CX#, T Li, XC Zeng, LX Liu, Dan Zhang*, XS Yao*, Yang Yu*. Neuroprotective effect of GJ-4 against cognitive impairments in vascular dementia by improving white matter damage. Phytomedicine. 2024, 132: 155877.
4. Zang CX, Wang L, Yang HY, Shang JM, Liu H, Zhang ZH, Ju C, Yuan FY, Li FY, Bao XQ, Zhang D. HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson’s disease models. Acta Pharmacologica Sinica. 2022, 43: 285-294.
5. Zang CX, Liu H, Shang JM, Yang HY, Wang L, Sheng CJ Zhang ZH, Bao XQ, Yu Y, Yao XS, Zhang D. Gardenia jasminoides J.Ellis extract GJ-4 alleviated cognitive deficits of APP/ PS1 transgenic mice, Phytomedicine. 2021, 93: 153780-153780.