1. 基因导向的活性天然产物的发现：挖掘并激活真菌中的沉默基因，发现常规实验条件下难以产生的活性化合物。
2. 活性天然产物的生物合成和合成生物学：解析结构独特的活性天然产物的生物合成途径；通过合成生物学技术实现活性化合物的生物制造。

1. Qian Wei#, Ze-Ping Wang#, Xiao Zhang*, Yi Zou*, Diaryl Ether Formation by a Versatile Thioesterase Domain，Journal of the American Chemical Society, 2022, 144, 22, 9554-9558.
2. Qian Wei, Haichun Zeng, and Yi Zou*, Divergent Biosynthesis of Fungal Dioxafenestrane Sesquiterpenes by the Cooperation of Distinctive Baeyer-Villiger Monooxygenases and α-Ketoglutarate-Dependent Dioxygenases, ACS Catalysis, 2021, 11, 948-957.
3. Qian Wei#, Jian Bai#, Daojiang Yan, Xiuqi Bao, Wenting Li, Bingyu Liu, Dan Zhang, Xiangbing Qi, Dequan Yu; Youcai Hu*, Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products, Acta Pharmaceutica Sinica B，2021, 11(2): 572-587.
4. Fenglin Jiang#, Anan Liu#, Qian Wei*, Youcai Hu*, Editing function of type II thioesterases in the biosynthesis of fungal polyketides, Chinese Chemical Letters, 2024,35,109504.