1. 发展合成复杂活性天然产物的新策略和新模式，突破由复杂活性天然产物进行新药创制的关 键瓶颈；
2. 基于靶点的新药设计与合成，开展小分子靶向抗肿瘤药物的研发工作；
3. 发展新型的合成方法学，解决复杂结构的高效构建、药物分子后期精准修饰等问题。

1. Jia-Xuan Liu#, Shi-Peng Zhang#, Feng-Sen Sun, Hui Li, Ya-Ling Gong*, Shi-Chao Lu*, Shu Xu*, Asymmetric total synthesis of naphthospironone A, Angewandte Chemie International Edition, 2023, 62, e202303229. (IF = 16.1)
2. Jun Zhao#, Wen-Jing Yang#, Yuan-Yi Lu, Yu Teng, Shi-Chao Lu*, Hong-Shuang Li*, Regioselective construction of 2-substituted indolines enabled by a rhodium-catalyzed decarboxylation–hydroacylation sequence, Organic Chemistry Frontiers, 2024, 11, 5495–5501. (IF = 4.6)
3. Tong-Bo Zhang#, Xi-Dong Guan#, Yan Gao, Shi-Chao Lu*, Bing-Long Li*, Metal- and light-free decarboxylative direct C–H alkylation of heteroarenes at room temperature, Organic & Biomolecular Chemistry, 2024, 22, 3439–3443. (IF = 2.9)
4. Shi-Chao Lu#, Fu-Qiang Wen#, Xi-Dong Guan*, Formal metal-free γ-arylation of 1,3- dicarbonyl compounds via an isomerisation/1,4-addition/[3,3]-sigmatropic rearrangement sequence, Green Chemistry, 2021, 23, 8964–8968. (IF = 11.034)
5. Shi-Chao Lu#, Yu-Yan Liang#, Liang Li#, Xiao-Lei Wang, Shi-Peng Zhang, Ya-Ling Gong, Shu Xu*, Synthesis of the tricyclic caged core of palhinine alkaloids based on a non-Diels−Alder-type strategy, Organic Letters, 2019, 21, 5567–5569. (IF = 6.091)
6. Hong-Shuang Li*#, Shi-Chao Lu#, Zhi-Xin Chang, Liqiang Hao, Fu-Rong Li, Chengcai Xia, Rhodium-catalyzed ring-opening hydroacylation of alkylidenecyclopropanes with chelating aldehydes for the synthesis of γ,δ-unsaturated ketones, Organic Letters, 2020, 22, 5145–5150. (IF = 6.005)
7. Jie Wu#, Ran Mu#, Zi-Jie Liu, Shi-Chao Lu*, Gang Liu*, Scalable total synthesis of a mycobactin T analogue utilizing a novel synthetic and protection strategy, Organic Chemistry Frontiers, 2019, 6, 2467–2470. (IF = 5.155)
8. Shi-Chao Lu#, Zhi-Xin Chang#, Yu-Liang Xiao, Hong-Shuang Li*, Regio- and stereoselective synthesis of 2-hydroxymethyl-1,3-enynes by rhodium-catalyzed decarboxylative C–C coupling, Advanced Synthesis & Catalysis, 2019, 361, 4831–4836. (IF = 5.851)