1、抗代谢疾病新药研发；
2、天然药物基于肠-器官轴的起效机制研究；
3、肠道菌与临床慢病机制研究。

1. Hui-Hui Guo#, Yan-Xing Han#, Xiao-Juan Rong#, Zhen Shen#, Hao-Ran Shen, Ling-Fei Kong, Yun-Dan Guo, Ji Zhou Li, Bo Xu, Tian-Le Gao*, Lu-Lu Wang*, Cai Tie*, Jian-Dong Jiang. Alleviation of allergic asthma by rosmarinic acid via gut-lung axis. Phytomedicine 2024, 126: 155470.
2. Hao-Ran Shen#, Zhi-Yu Wang#, Zhen Shen, Tong-Tong Liu, Yun-Dan Guo, Tian-Le Gao, Hui-Hui Guo*, Yan-Xing Han*, Jian-Dong Jiang. Bacterial butyrate mediates the anti-atherosclerotic effect of silybin. Biomedicine & Pharmacotherapy 2023, 169: 115916.
3. Hui-Hui Guo#, Hao-Ran Shen#, Lu-Lu Wang, Zhi-Gang Luo, Jin-Lan Zhang, Hong-Juan Zhang, Tian-Le Gao*, Yan-Xing Han*, Jian-Dong Jiang*. Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases. Biomedicine & Pharmacotherapy 2023, 163: 114754.
4. Hui-Hui Guo#, Hao-Ran Shen#, Ming-Ze Tang, Ning Sheng, Xiao Ding, Yuan Lin, Jin-Lan Zhang, Jian-Dong Jiang, Tian-Le Gao*, Lu-Lu Wang*, Yan-Xing Han*. Microbiota-derived short-chain fatty acids mediate the effects of dengzhan shengmai in ameliorating cerebral ischemia via the gut–brain axis, Journal of Ethnopharmacology, 2023, 306: 116158.
5. Hui-Hui Guo#, Chen Ma#, Wen-Sheng Zheng#, Yang Luo#, Cong Li, Xiao-Lin Li, Xiao-Lei Ma, Chen-Lin Feng, Ting-Ting Zhang, Yan-Xing Han, Zhi-Gang Luo, Yun Zhan, Rui Li, Lu-Lu Wang*, Jian-Dong Jiang*. Dual-Stimuli-Responsive Gut Microbiota-Targeting Berberine-CS/PT-NPs Improved Metabolic Status in Obese Hamsters, Adv. Funct. Mater., 2019, 29(14): 1808197.
6. Hui-Hui Guo#, Chen-Lin Feng#, Wen-Xuan Zhang#, Zhi-Gang Luo#, Hong-Juan Zhang, Ting-Ting Zhang, Chen Ma, Yun Zhan, Rui Li, Song Wu, Zeper Abliz, Cong Li, Xiao-Lin Li, Xiao-Lei Ma, Lu-Lu Wang*, Wen-Sheng Zheng*, Yan-Xing Han*, Jian-Dong Jiang*. Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases, Nat. Commun., 2019, 10(1): 1981.