1. 重点围绕结直肠癌等消化系统肿瘤在临床中出现的肿瘤转移、耐药、免疫疗法响应性不足及代谢-肿瘤共病问题开展研究工作，从肿瘤代谢适应角度阐明肿瘤干细胞特性维持及肿瘤免疫系统失能的新机制、新靶点，并基于此建立药物筛选体系开展抗肿瘤创新药物研发工作。
2. 从代谢物调控肠干细胞功能稳态的角度揭示炎性肠病（IBD）的发病新机制、新靶点，并基于新靶点进行创新药物发现工作。

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