1、基于质谱技术的蛋白质组学、修饰蛋白质组学、代谢组学等研究
2、创新药物的体内外代谢和转运评价研究
3、抗体药物等生物制品的质量控制研究

1. Sheng N, Zhang Z, Zheng H, Ma C, Li M, Wang Z, Wang L, Jiang J, Zhang J. Scutellarin Rescued Mitochondrial Damage through Ameliorating Mitochondrial Glucose Oxidation via the Pdk-Pdc Axis. Advanced Science. 2023 Nov;10(32):e2303584.
2. Ma C, Zhang W, Jing J, Wang Z, Sheng N*, An Z*, Zhang J*. Enalomics: A Mass Spectrometry-Based Approach for Profiling, Identifying, and Semiquantifying Enals in Biological Samples. Anal Chem. 2025 Jan 28;97(3):1507-1516.
3. Sheng N, Li R, Li Yang, Wang Z, Wang L, Li Y, Zhang J, Jiang J. Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect, Acta Pharmaceutica Sinica B, 2024, 7, 3140-3154.
4. Li Y#, Sheng N#, Wang K, Li Y, Jiang J, Zhang J. Azvudine alleviates SARS-CoV-2-induced inflammation by targeting myeloperoxidase in NETosis, Chinese Chemical Letters, 2024, 110238. doi.org/10.1016/j.cclet.2024.110238.
5. Ma Z#, Sheng N#, Zhang J. A feasible protocol to profile bile acids in dried blood spots from rats using a UHPLC-MS/MS method combining a surrogate matrix. Analyst. 2023 Oct 5;148(20):5190-5202.
6. Zhang Z#, Sheng N#, Liu X, Han B, Zhang B, Zhang J. Development and application of UHPLC-MS/MS method to quantify eculizumab in PNH patients. J Pharm Biomed Anal. 2025 Jun 15;258:116740.
7. Ma C#, Sheng N#, Li Y, Zheng H, Wang Z, Zhang J. A comprehensive perspective on the disposition, metabolism, and pharmacokinetics of representative multi-components of Dengzhan Shengmai in rats with chronic cerebral hypoperfusion after oral administration. J Ethnopharmacol. 2023 May 10;307:116212.
8. Ma C#, Sheng N#, Shi G, Zhang J, Zhang T. An efficient approach to probe the bioactive transdermal components of traditional Chinese herbal patches by UHPLC-MS: Gutong patch as a case. Phytomedicine. 2021 Dec;93:153776.
9. Ma C#, Sheng N#, Wu J, Wang L, Jiang J, Yu H, Zhang J. Active components of Dengzhan Shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca2+/CaMKII pathway. J Pharm Anal. 2024 Mar;14(3):435-438.
10. Zhang JL, Li YH, Wang LL, Liu HQ, Lu SY, Liu Y, Li K, Liu B, Li SY, Shao FM, Wang K, Sheng N, Li R, Cui JJ, Sun PC, Ma CX, Zhu B, Wang Z, Wan YH, Yu SS, Che Y, Wang CY, Wang C, Zhang Q, Zhao LM, Peng XZ, Cheng Z, Chang JB, Jiang JD. Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients. Signal Transduct Target Ther. 2021 Dec 6;6(1):414.
11. Sheng N, Zhao H, Chen X, Wang D, Li M, Wang Z, Zhang J, Jiang J. A novel derivatization strategy for profiling phosphate ester/anhydride metabolic network and application on glioma rats using HILIC-MS/MS. Talanta. 2021 Jun 1;228:122238.
12. Sheng N, Zheng H, Li M, Li M, Wang Z, Peng Y, Yu H, Zhang J. 4,5 caffeoylquinic acid and scutellarin, identified by integrated metabolomics and proteomics approach as the active ingredients of Dengzhan Shengmai, act against chronic cerebral hypoperfusion by regulating glutamatergic and GABAergic synapses. Pharmacol Res. 2020 Feb;152:104636.
13. Sheng N, Zheng H, Xiao Y, Wang Z, Li M, Zhang J. Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Chromatogr A. 2017 Sep 29;1517:97-107.
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16. 刘丽宏；张金兰；张文；生宁；马聪玉；安卓玲. 糖尿病合并心梗代谢标志物、检测试剂及试剂盒. ZL 2020 1 1336940.X. 2022.07.29