1、治疗特应性皮炎的新药发现及机制研究。
2、抗病毒药效学评价（流感病毒、HIV、HCV、呼吸道合胞病毒等）。

1. Wu Y#, Tang K#, Wang C, Song H, Zhou F, Guo Y*. Establishment of interpretable cytotoxicity prediction models using machine learning analysis of transcriptome features. Acta Pharm Sin B, 2025, 15(3):1344-1358.
2. Li J, Yao P, Tang K, Zhao X, Liu X, Liu Q, Wei T, Xuan H, Bian S, Guo Y*, Yang Z*, Zhang ZQ*, Zhang L*. Functional Aptamers In Vitro Evolution for Intranuclear Blockage of RNA-Protein Interaction. J Am Chem Soc. 2024 Sep 4;146(35):24654-24662.
3. Chen S#, Xin Y#, Tang K, Wu Y, Guo Y*. Nardosinone and aurantio-obtusin, two medicine food homology natural compounds, are anti-influenza agents as indicated by transcriptome signature reversion. Phytomedicine. 2023,108:154515.
4. Tang K#, Wu Y#, Chen S, Xin Y, Guo Y*. Discovery of the anti-influenza A virus activity of SB216763 and cyclosporine A by mining infected cells and compound cellular signatures. Chin Chem Lett. 2022,33(5):2541-2544.
5. Xin Y#, Chen S#, Tang K, Wu Y, Guo Y*. Identification of nifurtimox and chrysin as anti-influenza virus agents by clinical transcriptome signature reversion. Int J Mo. Sci. 2022, 23(4):2372.
6. Tang K#, Zhang X#, Guo Y*. Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry. Acta Pharm Sin B, 2020,10(5):789-798.
7. Zhang X, Tang K, Guo Y*. The antifungal isavuconazole inhibits the entry of lassa virus by targeting the stable signal peptide-GP2 subunit interface of lassa virus glycoprotein. Antiviral Res. 2020,174:104701.
8. Chen Q, Tang K, Guo Y*. Discovery of sclareol and sclareolide as filovirus entry inhibitors. J Asian Nat Prod Res. 2020,22(5):464-473.