研究方向为心脑血管及神经药理学与新药发现，主要从事心脑血管和抗炎免疫等分子靶点的发现和确证、药物筛选模型建立及筛选、活性化合物评价及机制研究等工作。主要研究内容包括：
1. 基于组蛋白去乙酰化酶的药物靶点确证及创新药物发现；
2. 神经修复相关脑卒中和多发性硬化的机制研究、新的药物作用靶点及药物发现；
3. 中药民族药的心脑血管系统作用、靶点及机制研究。

1. Guo M, Ma Y, Wang L, Ge R, Wang Y, Ma G, Du G, Li L*. Network Pharmacology Analysis and Experimental Study of Yinchen Against Neuroinflammation in Ischemic Stroke. Pharmaceuticals (Basel). 2025;18(12):1852.
2. Shen Y#, Yang H#, Gao P, Lu W, Cao Q, Yang H, Du G, Li L*. Identification of novel SIRT1 up-regulators using a cell-based high-throughput screening assay. Eur J Pharmacol. 2025;1005:178066.
3. Zhang JY#, Wang QR#, Yang HL#, Gao RM, Li M, Yang J, Li YH, Li L*, Ma SG*. Antiviral prenylated C6-C3 derivatives containing a methylenedioxyl group from the roots of Illicium brevistylum. Phytochemistry. 2025;235:114462.
4. Shen Y, Zhao J, Yang R, Yang H, Guo M, Ji B, Du G, Li L*. Panobinostat Attenuates Experimental Autoimmune Encephalomyelitis in Mice via Suppressing Oxidative Stress-Related Neuroinflammation and Mitochondrial Dysfunction. Int J Mol Sci. 2024;25(22):12035.
5. Zhang JY#, Yang HL#, Li WR, Gao RM, Li M, Wang RB, Yang J, Wang QR, Li YH, Li L*, Ma SG*. Bioactive prenylated c6-c3 derivatives from the roots of Illicium brevistylum. J Asian Nat Prod Res. 2024;26(11):1292-1304.
6. Chen S, Niu Z, Shen Y, Lu W, Zhao J, Yang H, Guo M, Zhang L, Zheng R, Du G*, Li L*. Naodesheng decoction regulating vascular function via G-protein-coupled receptors: network analysis and experimental investigations. Front Pharmacol. 2024;15:1355169.
7. Zhang JP#, Yang J#, Chen SH#, Gao RM, Li WR, Li M, Wang XJ, Wang HQ, Su GZ, Yong JY, Li YH, Li L*, Wang RB*, Ma SG*. Diverse prenylated C6-C3 derivatives from the stems and branches of Illicium ternstroemioides A. C. Smith with anti-inflammatory and antiviral activities. Fitoterapia. 2023;169:105615.
8. Li WR#, Zhao JY#, Li M, Wang XJ, Su GZ, Wang HQ, Li L*, Du GH, Wang RB*, Ma SG*. Bergamotane-type sesquiterpenes from the leaves and twigs of Illicium oligandrum and their anti-inflammatory activities. Phytochemistry. 2023;209:113617.
9. Shen Y, Yang R, Zhao J, Chen M, Chen S, Ji B, Chen H, Liu D, Li L*, Du G*. The histone deacetylase inhibitor belinostat ameliorates experimental autoimmune encephalomyelitis in mice by inhibiting TLR2/MyD88 and HDAC3/ NF-κB p65-mediated neuroinflammation. Pharmacol Res. 2022;176:105969.
10. Yang R, Shen YJ, Chen M, Zhao JY, Chen SH, Zhang W, Song JK, Li L*, Du GH*. Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats. J Asian Nat Prod Res. 2022;24(3):278-289.
11. Shen Y#, Yang R#, Zhou R, Lu W, Li L*, Niu Z, Chen M, Wang J, Wang Y, Fang L*, Du G*. Xiaoxuming Decoction Regulates Vascular Function by Modulating G Protein-Coupled Receptors: A Molecular Docking Study. Biomed Res Int. 2021;2021:5575443.
12. Shen Y, Zhang B, Pang X, Yang R, Chen M, Zhao J, Wang J, Wang Z, Yu Z, Wang Y, Li L*, Liu A*, Du G*. Network pharmacology-based analysis of Xiao-Xu-Ming Decoction on the Treatment of Alzheimer's Disease. Front. Pharmacol. 2020;11:595254.
13. Li L#, Li R#, Zacharek A, Wang F, Landschoot-Ward J, Chopp M, Chen J, Cui X*. ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke. Int J Mol Sci. 2020;21(12):4369.
14. Gao P#*, Li L#, Wei X, Wang M, Hong Y, Wu H, Shen Y, Ma T, Wei X, Zhang Q, Fang X, Wang L, Yan Z, Du GH, Zheng H, Yang G, Liu D, Zhu Z*. Activation of Transient Receptor Potential Channel Vanilloid 4 by DPP-4 (Dipeptidyl Peptidase-4) Inhibitor Vildagliptin Protects Against Diabetic Endothelial Dysfunction. Hypertension. 2020;75(1):150-162.