主要开展天然药物合成生物学研究，通过天然药物生物合成基因的挖掘及其酶的表征，对其生物合成途径进行解析，在酵母中构建生物合成途径，通过微生物细胞工厂高效生产天然药物，拓展药物来源。
1. 高活性非天然人参皂苷的合成生物学研究：在对天然人参皂苷生物合成途径进行设计及改造的基础上，在酿酒酵母中构建非天然人参皂苷的生物合成途径，获得高产工程菌，通过微生物细胞工厂实现高活性非天然人参皂苷的绿色生物制造。
2. 通过工程菌生产蛋白类药物的研究：克隆或人工合成蝎毒蛋白、超氧化物歧化酶等蛋白类药物基因，将其转入大肠杆菌或酵母细胞，获得高产工程菌，通过基因工程技术探索蛋白类药物生产的新途径。

1. Tianjiao Chen, Jingjing Chen, Xiaoyan Sun, Ting Gong, Jinling Yang*, Ping Zhu*. Engineering of 10-deacetylbaccatin III-10-β-O-acetyltransferase from Taxus species for efficient acetylating non-natural substrates into Taxol in Nicotiana benthamiana. Plant Biotechnology Journal, 2026, 0: 1-16.
2. Chen Zhou, Tianjiao Chen, Andi Gu, Zongfeng Hu, Yan Li, Ting Gong, Jingjing Chen, Jinling Yang*, Ping Zhu*. Combining protein and metabolic engineering to achieve green biosynthesis of 12β-O-Glc-PPD in Saccharomyces cerevisiae. Green Chemistry, 2023, 25(4): 1356-1367.
3. Fenglin Jiang, Chen Zhou, Yan Li, Haidong Deng, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang*, Ping Zhu*. Metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides F2 and 3β,20S-Di-O-Glc-DM. Acta Pharmaceutica Sinica B, 2022, 12(7): 3167-3176.
4. Zongfeng Hu, Andi Gu, Lan Liang, Yan Li, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang*, Ping Zhu*. Construction and optimization of microbial cell factories for sustainable production of bioactive dammarenediol-II glucosides. Green Chemistry, 2019, 21: 3286-3299.
5. Huichao Liang, Zongfeng Hu, Tingting Zhang, Ting Gong, Jingjing Chen, Ping Zhu, Yan Li, Jinling Yang*. Production of a bioactive unnatural ginsenoside by metabolically engineered yeasts based on a new UDP-glycosyltransferase from Bacillus subtilis. Metabolic Engineering, 2017, 44: 60-69.
6. Yanxin Li, Xiaoyan Sun, Yanxin Liu, Hua Sun, Chen Zhou, Yu Peng, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang* and Ping Zhu*. Construction and optimization of a yeast cell factory for producing active unnatural ginsenoside 3β-O-Glc2-DM. Acs Synthetic Biology, 2024, 13(11): 3677-3685
7. Xiaoyan Sun, Yu Peng, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang*, Ping Zhu*. Engineering a yeast cell factory for high-level production of an unnatural ginsenoside 3β-O-Glc-DM. Microbial Cell Factories, 2026, 25: 83
8. Chen Zhou, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang*, Ping Zhu*. Production of a novel protopanaxatriol-type ginsenoside by yeast cell factories. Bioengineering, 2023,10: 463.
9. Tingting Zhang, Ting Gong, Zongfeng Hu, Andi Gu, Jinling Yang*, Ping Zhu*. Enzymatic synthesis of unnatural ginsenosides using a promiscuous UDP-glucosyltransferase from Bacillus subtilis. Molecules, 2018, 23: 2797.
10. Yang Jinling, Hu Zongfeng, Zhang Tingting, Gu Andi, Gong Ting, Zhu Ping. Progress on the studies of the key enzymes of ginsenoside biosynthesis. Molecules, 2018, 23: 589.
11. Jinling Yang, Xinglun Li, Fenglin Jiang, Ting Gong, Jingjing Chen, Tianjiao Chen, Ping Zhu*. High-level soluble expression of human Cu,Zn superoxide dismutase with high activity in Escherichia coli. World Journal of Microbiology and Biotechnology, 2020, 36: 106.
12. Yang Jinling, Zhu Ping, Cheng Guifang. Expression, purification and characterization of an analgesic peptide from Buthus martensii Karsch in Pichia pastoris. World Journal of Microbiology and Biotechnology, 2009, 25: 2053-2056.
13. Wang Qinghua, Liang Lan, Liu Wancang, Gong Ting, Chen Jingjing, Hou Qi, Yang Jinling*. Enhancement of recombinant BmK AngM1 production in Pichia pastoris by regulating gene dosage, co-expressing with chaperones and fermenting in fed-batch mode. Journal of Asian Natural Products Research, 2017, 19(6): 581-594.
14. Yu Peng, Yue Wang, Jingjing Chen, Tianjiao Chen, Jinling Yang, Ting Gong*, Ping Zhu*. A fungal CYP from Beauveria bassiana with promiscuous steroid hydroxylation capabilities. Chinese Chemical Letters, 2024, 35: 108818.
15. Dan Ye#, Yizhen Shao#, Wenrui Li#, Zhenjia Cui, Ting Gong, Jinling Yang, Haiqiang Wang, Jungui Dai, Keping Feng, Ming Ma, Shuanggang Ma*, Yunbao Liu*, Ping Zhu*, Shishan Yu*. Characterization and engineering of two highly paralogous sesquiterpene synthases reveal a regioselective reprotonation switch. Angewandte Chemie International Edition, 2024, 136(13): e202315674.
16. Xinyi Guo, Zhiwei Chen, Chen Gao, Lingzhi Zhang, Yanxin Liu, Modi Lin, Ping Zhu, Jinling Yang, Zhe Wang, Jinlan Zhang, Hua Sun*. 20S-O-Glc-DM treats metabolic syndrome-induced heart failure through regulating gut flora. European Journal of Pharmacology, 2024, 982: 176946. 17. Xinyi Guo, Zihan Chen, Yanxin Liu, Zhiwei Chen, Modi Lin, Lingzhi Zhang, Ping Zhu, Jinling Yang, Zhe Wang, Jinlan Zhang, Hua Sun*. 20S-O-Glc-DM treats left ventricular diastolic dysfunction by modulating cardiomyocyte mitochondrial quality and excess autophagy. Phytomedicine, 2024, 133: 155911.
18. 张婷婷, 梁会超, 巩婷, 胡宗风, 顾安頔, 杨金玲*, 朱平*. 人参糖基转移酶PgUGT74AE2催化生成新型人参三醇皂苷研究. 药学学报, 2018, 53(9): 1565-1570.
19. 杨金玲, 高丽丽, 朱平*. 蝎毒镇痛活性肽基因BmK AngM1的密码子优化及其真核表达分析. 药学学报, 2012, 47(10): 1389-1393.
20. 梁兰, 王庆华, 胡宗风, 朱平, 侯琦, 杨金玲*. 蝎毒活性肽 BmK AngMl 的定点突变及其抗炎活性研究. 药学学报, 2017, 52(6): 1007-1011.
21. 梁会超, 高丽丽, 胡宗风, 巩婷, 陈晶晶, 杨金玲*, 朱平*. 人参达玛烯二醇-II 合酶在酿酒酵母中的表达、定位及功能研究. 药学学报, 2016, 51(6): 998-1003.
22. 王庆华, 高丽丽, 梁会超, 杜国华, 巩婷, 杨金玲*, 朱平*. 利用反义RNA技术抑制酿酒酵母羊毛甾醇合酶基因的表达. 药学学报, 2015, 50(1): 118-122.
23. 李星论, 巩婷, 陈晶晶, 陈天娇, 乔云明, 杨金玲*, 朱平*. 重组人源超氧化物歧化酶研究进展. 中国医药生物技术, 2019, 14(4): 352-357.