EN

科研队伍

您现在的位置: 首页> 科研队伍> 研究员

研究员

李帅

职 称:研究员

所属科室:天然药物化学研究室

导师类别:博士生导师

联系方式:010-63164628

所属重点实验室:天然药物活性物质与功能国家重点实验室

个人简介

2001年毕业于北京中医药大学,获中药学专业博士学位。曾担任黑龙江中医药大学药学院中药化学教研室助教、讲师,日本明治药科大学天然药物学访问学者,中国协和医科大学药物研究所药学专业博士后。现在中国医学科学院药物研究所天然药物化学研究室工作,研究员,博士研究生指导教师,世界中医药联合学会中药化学专业委员会常务理事,主要从事中药化学的基础和应用研究。

研究方向


1、具有抗炎免疫和神经系统活性的中药有效成分研究及新药研发。
2、中药有效成分及标准物质的研究;
3、常用中药及复方药效物质基础及质量标准研究。

发表论文


1. Hepatoprotective glucosyloxybenzyl 2-hydroxy-2-isobutylsuccinates from Pleione yunnanensis. Shao-wei Han, Xiao-juan Wang, Bao-song Cui, Hua Sun, Hui Chen, Daneel Ferreira, Shuai Li *, Mark T. Hamann *. J. Nat. Prod, 2021, 84(3), 738-749.
2. Phenanthrene, 9,10-dihydrophenanthrene and bibenzyl enantiomers from Bletilla striata with their antineuroinflammatory and cytotoxic activities. Mo-Han Sun, Xian-Jie Ma, Si-Yuan Shao, Shao-Wei Han, Jian-Wei Jiang, Jian-Jun Zhang, Shuai Li*. Phytochemistry, 2021,182,112609.
3. New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity. Shao Si-Yuan, Li Ruo-Fei, Sun Hua, Li Shuai*. Chin J Nat Med 2021, 19(5): 376-384.
4. New seco-dibenzocyclooctadiene lignans with nitric oxide production inhibitory activity from the roots of Kadsura longipedunculata. Xinzhu Qi, Jiabao Liu, Jiabao Chen, Qi Hou, Shuai Li*. Chin Chem Lett, 2020, 31 (2): 423-426.
5. Sesquiterpenoids, phenolic and lignan glycosides from the roots and rhizomes of Clematis hexapetala Pall. and their bioactivities. Lu Cai, Si-Yuan Shao, Shao-Wei Han, Shuai Li*. Bioorg Chem, 2020, 104: 104312.
6. Hepatoprotective lignans and triterpenoids from the roots of Kadsura longipedunculata. Si-Yuan Shao, Xin-Zhu Qi, Hua Sun, Shuai Li*. Fitoterapia, 2020, 142: Article 104487.
7. Two new phenanthrenequinones with cytotoxic activity from the tubers of Pleione bulbocodioides. Si-Yuan Shao, Chao Wang, Shao-Wei Han, Shuai Li*. Phytochemistry Letters, 2020, 35, 6-9.
8. Enantiotopic bi (9,10-dihydro) phenanthrene and phenanthrene/bibenzyl dimers with cytotoxic activity from the pseudobulbs of Pleione bulbocodioides. Chao Wang, Siyuan Shao, Shaowei Han, Shuai Li*. Fitoterapia, 2019, 138: article 104313.
9. Hepatoprotective Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata. Jiabao Liu, Pankaj Pandey, Xiaojuan Wang, Kamesha Adams, Xinzhu Qi, Jiabao Chen, Hua Sun, Qi Hou, Daneel Ferreira, Robert J. Doerksen, Shuai Li * and Mark T. Hamann*. J Nat Prod, 2019, 82(10):2842-2851.
10. Phenanthrenequinone enantiomers with cytotoxic activities from the tubers of Pleione bulbocodioides. Si-Yuan Shao, Chao Wang, Shao-Wei Han, Mo-Han Sun, Shuai Li*. Org Biomol Chem, 2019, 17(3), 567-572.
11. Structural characterization and immunological activity of polysaccharides from the tuber of Bletilla striata. Yirui Wang, Shaowei Han, Ruofei Li, Baosong Cui, Xianjie Ma, Xinzhu Qi, Qi Hou, Mingbao Lin, Jinye Bai, Shuai Li*. Int J Biol Macromol, 2019, 122(2): 628-635.
12. Hepatoprotective activity of glucosyloxybenzyl succinate derivatives from the pseudobulbs of Pleione bulbocodioides. Shaowei Han, Chao Wang, Baosong Cui, Hua Sun, Jianjun Zhang, Shuai Li*. Phytochemistry, 2019,157, 71-81.
13. Computationally Assisted Assignment of the Kadsuraols, a Class of Chemopreventive Agents for the Control of Liver Cancer. Xiaojuan Wang, Jiabao Liu, Pankaj Pandey, Frank R. Fronczek, Robert J. Doerksen, Jiabao Chen, Xinzhu Qi, Peicheng Zhang, Daneel Ferreira, Frederick A. Valeriote, Hua Sun, Shuai Li*, and Mark T. Hamann*. Organic Letters, 2018, 20(18): 5559-5563.
14. Hepatoprotective Dibenzocyclooctadiene and Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata. Jiabao Liu, Pankaj Pandey, Xiaojuan Wang, Xinzhu Qi, Jiabao Chen, Hua Sun, Peicheng Zhang, Yuanqing Ding, Daneel Ferreira, Robert J. Doerksen, Mark T. Hamann,*and Shuai Li *. J Nat Prod, 2018, 81(4):846-857.
15. Triterpenoids from the Leaves of Ilex chinensis. Wen-Qi Xia, Ruo-Fei Li, Jia-Bao Liu, Bao-Song Cui, Qi Hou, Hua Sun, Shuai Li*. Phytochemistry, 2018,148, 113-121.
16. New Triterpenoid saponins from the Leaves of Ilex chinensis. Ruo-Fei Li , Wen-Qi Xia, Jia-Bao Liu, Bao-Song Cui, Qi Hou, Hua Sun, Shuai Li*. Fitoterapia, 2018, 131:134-140.
17. New dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus. Yi-Rui Wang, Bao-Song Cui, Shao-Wei Han, Shuai Li*. J Asian Nat Prod Res, 2018, 20(11): 1019-1027.
18. 四季青中三萜类化学成分的研究. 李若斐,夏文绮,崔保松,李帅*. 中草药,2018,49(7):1513 -1519。
19. Assignment of the absolute configuration of hepatoprotective highly oxygenated triterpenoids using X-ray, ECD, NMR J-based configurational analysis and HSQC overlay experiments. Xiaojuan Wang, Jiabao Liu, Pankaj Pandey, Jiabao Chen, Frank R. Fronczek, Stuart Parnham, Xinzhu Qi, Robert J. Doerksen, Daneel Ferreira, Hua Sun, Shuai Li*, Mark T. Hamann*. BBA-GEN SUBJECTS, 2017, 1861(12): 3089-3095.
20. Tamarixinin A Alleviates Joint Destruction of Rheumatoid Arthritis by Blockade of MAPK and NF-kB Activation. Yuanyuan Zhuang, Jiabao Liu, Pei Ma, Jinye Bai, Yasi Ding, Hui Yang, Yannan Fan, Mingbao Lin*, Shuai Li* and Qi Hou*. Frontiers in Pharmacology, 2017, 8, article 538.
21. Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-type Nortriterpenoid using X-Ray Diffraction. Xiaojuan Wang , Frank R. Fronczek, Jiabao Chen , Jiabao Liu, Daneel Ferreira, Shuai Li*, Mark T. Hamann*. Molecules, 2017, 22,65.
22. 中药白及的化学成分研究. 马先杰,崔保松,韩少伟,李帅*.中国中药杂志,2017,42(8):1578-1584。
23. 南五味子根中木脂素和三萜的化学成分研究. 亓新柱,刘佳宝,陈佳宝,李帅*. 中草药, 2017,48(11):2164-2171。
24. Militarine 善慢性脑缺血大鼠认知功能障碍及白质损伤的研究. 王耀, 赵香玉, 李新娅, 李帅, 张建军*. 药学学报,2016, 51 (5): 738-742。
25. 四季青化学成分的研究. 夏文绮,崔保松,李帅*. 中草药,2016, 47 (8), 1272-1277.
26. Anti-inflammatory Hydrolyzable Tannins from Myricaria bracteata. Jia-Bao Liu, Ya-Si Ding,Ying Zhang, Jia-Bao Chen, Bao-Song Cui, Jin-Ye Bai, Ming-Bao Lin, Qi Hou, Pei-Cheng Zhang, Shuai Li*. J Nat Prod, 2015, 78 (5): 1015-1025.
27. New triterpenoid saponins from the leaves of Cyclocarya paliurus. Baosong Cui, Shuai Li*. Chin Chem Lett, 2015, 26(5): 585-589.
28. New Triterpenoid Saponins from the aerial parts of Comastoma pedunculatum. Yi Yuan, Yongqi Qiao, Baosong Cui, Li Tang, Shaopeng Yuan, Qi Hou, Shuai Li*. J Asian Nat Prod Res, 2015, 17(3): 239-247.
29. 南五味子根的化学成分研究. 陈佳宝,刘佳宝,崔保松,李帅*. 中草药,2015, 46 (2): 178-184.
30. 独蒜兰中丁二酸苄酯苷类化学成分的研究. 韩少伟,王超,崔保松,李帅*. 中国中药杂志 2015,40 (5): 908-914.
31. Hepatoprotective Saikosaponin homologs from Comastoma pedunculatum. Baosong Cui, Yongqi Qiao, Yi Yuan, Li Tang, Hui Chen, Yan Li, Shuai Li*. Planta Medica, 2014, 80(17), 1647-1656.
32. 独蒜兰的化学成分研究. 王超,韩少伟,崔保松,王晓娟,李帅*. 中国中药杂志 2014,39 (3): 442-447.
33.云南独蒜兰的化学成分研究. 王晓娟,崔保松,王超,李帅*.中国中药杂志 2014,39 (5): 851-856.

专著


1. 中国食用药用真菌化学 编委 上海科学技术文献出版社 2016
2. 天然产物化学研究 编委 中国协和医科大学出版社 2006

专利


1. 白及有效部位在治疗老年性痴呆的用途. 李帅,张建军,石建功,徐瑞明,韩少伟. 专利号:ZL 2016 1 0105924.7
2. 可水解鞣质类化合物、其药物组合物及其用途. 李帅,侯琦,刘佳宝,袁绍鹏,白金叶,丁亚思,陈佳宝,庄媛媛. 专利号:ZL 2016 1 0262668.2 。
3. 金银花提取物,其制备方法和应用. 石建功,李帅,王素娟,杨永春,安玉伟,韩丰年. 专利号:ZL 2006 1 0083556.7。

科技奖励

1. 2010年,“黑龙江产中草药化学成分研究”,匡海学,李帅,李国玉,张彦龙,王秋红。黑龙江省科技进步奖,自然类,一等奖。