1. 新药临床前药代动力学及PK/PD研究
2. 血脑屏障与药物转运研究
3. 药物代谢酶和转运蛋白相关的药物相互作用机制研究

1. Tao A, Lin Y, Feng J, Luo H, Qu K, Kang Y, Yu H, Chuangjun L, Ma J, Huang W, Sheng L*, Zhang D*, Zang Y*, Peng Y*. Discovery of Novel Pyrano[3,2-a]carbazole Alkaloid Derivatives against Ischemic Stroke by Targeting ADGRL3. J Med Chem. 2026;69(6):7012-7031.
2. Luo L, Chang Y, Zhang W, Liu X, Ge J, Chen J, Li Y, Zhang D*, Sheng L*. 7-Hydroxycoumarin and its conjugated metabolites interact with organic anion transporters 1 and 3 in vitro and in vivo. Chem Biol Interact. 2025;405:111293.
3. Tian H, Liu Y, Lin S, Deng J, Zhang Q, Hao F, Tang Y, Xiong T, Zhang K, Shi G, Luo L, Peng S, Sheng L*, Ji M*, Xu H*. Design, Synthesis, and Biological Evaluation of Novel Fms-Like Tyrosine Kinase 3/VEGFR2/Histone Deacetylase Inhibitors for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2025;68(5):5736-5759.
4. Chang Y, Zhang W, Liu X, Luo L, Chen J, Zhao Y, Chen X, Ji M*, Sheng L*. Interspecies comparison on the O-methylation metabolism of LJR003, a novel immunomodulator targeting acetyl-CoA acetyltransferase 1. J Pharm Biomed Anal. 2025;262:116894.
5. Jiang J, Luo L, Zhang Z*, Liu X, Chen N, Li Y, Sheng L*. The Active Glucuronide Metabolite of the Brain Protectant IMM-H004 with Poor Blood-Brain Barrier Permeability Demonstrates a High Partition in the Rat Brain via Multiple Mechanisms. Pharmaceutics. 2024;16(3):330.
6. Zhang Y, Deng J, Tian H, Qi H, Xiong T, Lin S, Dong Y, Luo L, Wu D, Zhang K, Ji M, Du T, Sheng L*, Chen X*, Xu H*. Design, Synthesis, and Bioevaluation of Novel Reversibly Photoswitchable PI3K Inhibitors Based on Phenylazopyridine Derivatives toward Light-Controlled Cancer Treatment. J Med Chem. 2024;67(5):3504-3519.
7. Zhou J, Wang W, Liu D, Xu S, Wang X, Zhang X, Wang X, Li Y, Sheng L*, Wang X*, Xu B*. Discovery of 2-Ethoxy-5-isobutyramido-N-1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects. J Med Chem. 2024;67(1):213-233.