基于合成生物学的天然药物化学和新药创制研究：
1. 基因驱动的活性天然产物发现及其形成机制：以抗性基因和结构基因为导向，挖掘特定靶标的天然活性分子和特殊骨架的新颖结构。阐明药用天然产物生物合成中的催化机制及调控机制，挖掘功能独特的生物合成酶，阐释天然产物的内源性功能及作用机制。
2. 天然药物合成生物学：通过合成生物学技术获取高价值的天然活性成分，并进行异源合成和结构优化，以摆脱对野生资源的依赖。
3. 基于天然产物的创新药物研究。
职 称：研究员
所属科室：国家重点实验室
导师类别：博士生导师
联系方式：huyoucai@imm.ac.cn
所属重点实验室：天然药物及核药基础与新药创制全国重点实验室；
国家卫生和计划生育委员会天然药物生物合成重点实验室；
基于合成生物学的天然药物化学和新药创制研究：
1. 基因驱动的活性天然产物发现及其形成机制：以抗性基因和结构基因为导向，挖掘特定靶标的天然活性分子和特殊骨架的新颖结构。阐明药用天然产物生物合成中的催化机制及调控机制，挖掘功能独特的生物合成酶，阐释天然产物的内源性功能及作用机制。
2. 天然药物合成生物学：通过合成生物学技术获取高价值的天然活性成分，并进行异源合成和结构优化，以摆脱对野生资源的依赖。
3. 基于天然产物的创新药物研究。
1. A Unique CYP450 Enzyme Unlocks Antrodia Camphorata Lanostane Triterpenoid Diversity Through Oxidation and Skeletal Rearrangement. Shungang Jiao#, Wentao Sun#, and Youcai Hu*. Angewandte Chemie International Edition, 2026, 65, e21539.
2. Targeting SCAMP2 by a natural product auxarconjugatin B for glioblastoma therapy via restoring aspartate metabolic flux. Changhui Shang#, Wan Li#, Qianlun Pu#, Bingyu Liu, Chen Zhang, Yiqing Tan, Yihui Yang, Dan Du*, Jinhua Wang*, Youcai Hu*. Acta Pharmaceutica Sinica B, 2026, In Press.
3. Radical Ring Expansion Catalyzed by an Ketoglutarate-Dependent Dioxygenase in the Biosynthesis of Tropolones. Mingjie Liu#, Jiawang Liu#, Songlin Bai#, Ziang Chen, Yaling Wu, Dan Du*, Xiangbing Qi*, Xiaojing He*, and Youcai Hu*. Journal of the American Chemical Society, 2025, 147(35), 32167−32177.
4. Full biosynthetic pathway of pyrrolobenzoxazines. Kunya Wang, Bingyu Liu, Daojiang Yan, Jian Bai, Haibo Yu, Youcai Hu*. Chinese Chemical Letters, 2025, 36(1), 109811.
5. Editing function of type II thioesterases in the biosynthesis of fungal polyketides. Fenglin Jiang#, Anan Liu#, Qian Wei*, Youcai Hu*. Chinese Chemical Letters, 2024, 35(10), 109504.
6. Tandem intermolecular [4 + 2] cycloadditions are catalysed by glycosylated enzymes for natural product biosynthesis. Jiawang Liu#, Jia-Yan Lu#, Chen Zhang#, Qingyang Zhou#, Cooper S. Jamieson, Changhui Shang, K. N. Houk*, Jiahai Zhou*, and Youcai Hu*. Nature Chemistry, 2023, 15(8), 1083-1090.
7. Flavin-Dependent Monooxygenase-Mediated 1,2-Oxazine Construction via Meisenheimer Rearrangement in the Biosynthesis of Paeciloxazine. Daojiang Yan#, Kunya Wang#, Songlin Bai#, Bingyu Liu#, Jian Bai, Xiangbing Qi, and Youcai Hu*. Journal of the American Chemical Society, 2022, 144(9), 4269-4276.
8. Biosynthesis of rumbrins and inspiration for discovery of HIV inhibitors. Beifen Zhong#, Jun Wan#, Changhui Shang#, Jiajia Wen, Yujia Wang, Jian Bai, Shan Cen*, Youcai Hu*. Acta Pharmaceutica Sinica B, 2022, 12(11): 4193-4203.
9. Enzymatic Dimerization in the Biosynthetic Pathway of Microbial Natural Products. Jiawang Liu#, Anan Liu# and Youcai Hu*. Natural Product Reports, 2021, 38(8), 1469-1505.
10. Self-Resistance in the Biosynthesis of Fungal Macrolides Involving Cycles of Extracellular Oxidative Activation and Intracellular Reductive Inactivation. Yalong Zhang, Jian Bai, Le Zhang, Chen Zhang, Bingyu Liu, and Youcai Hu*. Angewandte Chemie International Edition, 2021, 60(12), 6639–6645.
11. Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products. Qian Wei#, Jian Bai#, Daojiang Yan, Xiuqi Bao, Wenting Li, Bingyu Liu, Dan Zhang, Xiangbing Qi, Dequan Yu, Youcai Hu*. Acta Pharmaceutica Sinica B, 2021, 11(2), 572-587.
12. Enzymatic Intermolecular Hetero-Diels–Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes.Qibin Chen#, Jie Gao#, Cooper Jamieson, Jiawang Liu, Masao Ohashi, Jian Bai, Daojiang Yan, Bingyu Liu, Yongsheng Che, Yanan Wang, K. N. Houk*, and Youcai Hu*. Journal of the American Chemical Society, 2019, 141(36), 14052-14056.
13. Biosynthesis of Heptacyclic Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide. Shu-Shan Gao#, Tao Zhang#, Marc Garcia-Borras, Yiu-Sun Hung, John M. Billingsley, K. N. Houk*, Youcai Hu* and Yi Tang*. Journal of the American Chemical Society, 2018, 140(22), 6991−6997.
14. Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids.Jian Bai, Rong Mu, Man Dou, Daojiang Yan, Bingyu Liu, Qian Wei, Jun Wan, Yi Tang, Youcai Hu*. Acta Pharmaceutica Sinica B, 2018, 8(4), 687–697.
15. A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Jian Bai#, Daojiang Yan#, Tao Zhang, Yongzhi Guo, Yunbao Liu, Yi Zou, Mancheng Tang, Bingyu Liu, Qiong Wu, Shishan Yu*, Yi Tang*, and Youcai Hu*. Angewandte Chemie International Edition, 2017, 56(17), 4782-4786.