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研究员

强桂芬

职 称:研究员

所属科室:国家药物筛选中心

导师类别:博士生导师

联系方式:010-63165313

所属重点实验室:脑血管病新药发现及晶型研究北京市重点实验室

研究方向

研究方向为代谢性疾病药理学与新药发现,聚焦于抗代谢性疾病药物新靶标发现、高通量药物筛选、药效学评价、机制探索与成药性研究。

发表论文

1. Hu L, Zhang Z, Xu T, Ma P, Wang Z, Zhang L, Chen J, He P, Yang X, Du G, Lian F*, Li X*, Qiang G*. Jiangtang Tiaozhi Formula alleviates obesity by enhancing adipose thermogenesis via TGR5-mediated gut-liver-adipose axis. Phytomedicine. 2025,150:157608.
2. Ma P, Xiao J, Hou B, He P, Yang X, Wang Y, Wang Z, Xu T, Yang X, Zhu X, Xiang S, Li S, Du G*, Ying J*, Qiang G*. Carbonic anhydrase 2 mediates anti-obesity effects of black tea as thermogenic activator. Food Sci Hum Well. 2024, 13(5):2917-2936.
3. Hou B#, Ma P#, Yang X#, Zhao X, Zhang L, Zhao Y, He P, Zhang L, Du G*, Qiang G*. In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy. J Ethnopharmacol. 2024;319(Pt 2):117281.
4. Xu T#, He P#, namWangdu S#, Xu C, Hou B, Ma P, Wang Z, Zhang L, Du G, Ring T*, Ji T*, Qiang G*. Revealing the improvement of diabetes by Si Wei Jiang Huang Tang San through ERK/HIF1α signaling pathway via network pharmacology. J Ethnopharmacol. 2024;319(Pt 2):117254.
5. Wang ZJ, Ma P, Xu CY, Xu TS, Zhang L, He P, Hou BY, Yang XY, Du GH, Ji TF*, Qiang GF*. Identification of a novel hypoglycemic small molecule, trans-2, 4-dimethoxystilbene by rectifying gut microbiota and activating hepatic AMPKα-PPARγ pathway through gut-liver axis. Biomed Pharmacother. 2024;176:116760.
6. Wang Y#, Ma P#, Wang Z, Sun M, Hou B, Xu T, Li W, Yang X, Du G, Ji T*, Qiang G*. Uncovering the effect and mechanism of Panax notoginseng saponins on metabolic syndrome by network pharmacology strategy. J Ethnopharmacol. 2023;300:115680.
7. Li N, Yin L, Shang J, Liang M, Liu Z, Yang H, Qiang G*, Du G, Yang X*. Kaempferol attenuates nonalcoholic fatty liver disease in type 2 diabetic mice via the Sirt1/AMPK signaling pathway. Biomed Pharmacother. 2023;165:115113.
8. Qiang G, Kong WH, Fang D, McCann M, Yang X, Du G, Blüher M, Zhu J, Liew CW*. The obesity-induced transcriptional regulator TRIP-Br2, mediates visceral fat endoplasmic reticulum stress-induced inflammation. Nat Commun. 2016, 7: 11378.
9. Wang X#*, Li Y#, Qiang G#, Wang K, Dai J, McCann M, Munoz MD, Gil V, Yu Y, Li S, Yang Z, Xu S, Cordoba-Chacon J, De Jesus DF, Sun B, Chen K, Wang Y, Liu X, Miao Q, Zhou L, Hu R, Ding Q, Kulkarni RN, Gao D, Blüher M, Liew CW*. Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice. Nat Commun. 2022, 13(1):7323.