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科研队伍

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研究员

张金兰

职 称:研究员、准聘副教授

所属科室:药物分析研究室

导师类别:博士生导师

联系方式:zhjl@imm.ac.cn

所属重点实验室:天然药物活性物质与功能国家重点实验室

个人简介

本科毕业于北京医科大学(现北京大学医学部),获得理学学士学位,研究生毕业于中国协和医科大学(现北京协和医学院),先后获得理学硕士和药物分析专业博士学位。现任北京协和医学院药物分析学系副系主任,药物分析研究室副主任。主要从事药物分析和药物代谢的研究工作,作为项目负责人承担和完成了国家自然科学基金、重大新药创制专项、卫生行业专项等国家和省部级研究课题,2009年度入选教育部新世纪优秀人才计划。现兼任《中国药学》(英文版)、《药物分析杂志》、《质谱学报》、《药学学报》、Journal of Separation Science等杂质编委。中国药学会医药生物分析专业委员会副主任委员和国际反兴奋剂组织(WADA)实验室认可评审员等。

研究方向

主要研究方向是药物分析新技术及方法研究与应用。
已构建色谱质谱联用和多维数据分析的药物关键分析技术平台,重点解决化学药、中药、抗体药关键质量属性和体内药效物质关键分析技术瓶颈。
开展创新药物质量分析方法研究和标准制定,支撑创新药临床前药学研究,完成临床研究注册申报。
建立体内药物及其代谢物分析方法,开展药代动力学研究。
开展代谢组学/蛋白组学/活性化学蛋白组学分析技术研究,发现药物靶标和探索作用机制,诠释中药作用物质基础和机制。

发表论文

Lipoprotein proteome profile: novel insight into hyperlipidemia, Clinical and Translational Medicine.Miao Lin#, Menglin Li#, Hao Zheng, Haidan Sun, Jinlan Zhang*. 2021, doi=10.1002/ctm2.361.
Harnessing affinity-based protein profiling to reveal a novel target of nintedanib. Xiong Chen#, Menglin Li#, Manru Li, Dongmei Wang*, Jinlan Zhang*. Chem Commun., 2021, 57, 3139-3142.
Characterization of the protein and peptide of excipient zein by the multienzyme digestion coupled with nano-LC-MS/MS. Menglin Li, Hao Zheng, Miao Lin, Wenwen Zhu, Jinlan Zhang*. Food Chemistry, 2020, 321: 126712.
Integrating Intact Mass Analysis and Middle-Down Mass Spectrometry Approaches to Effectively Characterize Trastuzumab and Adalimumab Structural Heterogeneity. Wenwen Zhu#, Menglin Li#, Jinlan Zhang*. Journal of Proteome Research, 2020. doi=10.1021/acs.jproteome.0c00373.
Impaired tricarboxylic acid cycle flux and mitochondrial aerobic respiration during isoproterenol induced myocardial ischemia is rescued by bilobalide. Zhe Wang#, Fan Zhang#, Wei Liu, Ning Sheng, Hua Sun*, Jinlan Zhang*. Journal of Pharmaceutical Analysis, 2020. doi.org/10.1016/j.jpha.2020.08.008.
4,5 caffeoylquinic acid and scutellarin, identified by integrated metabolomics and proteomics approach as the active ingredients of Dengzhan Shengmai, act against chronic cerebral hypoperfusion by regulating glutamatergic and GABAergic synapses. Ning Sheng#, Hao Zheng#, Min Li, Menglin Li, Zhe Wang, Ying Peng, Haibo Yu*, Jinlan Zhang*. Pharmacological Research, 2020, 152C, 104636.
Global profiling and identification of bile acids by multi-dimensional data mining to reveal a way of eliminating abnormal bile acids. Miao Lin , Xiong Chen , Zhe Wang , Dongmei Wang**, Jin-Lan Zhang*,Analytica Chimica Acta,10.1016/j.aca.2020.07.067.
Discover and identify unknown alkylation DNA adducts induced by sulfonates using prediction driven -MRM-profiling strategy. Yu Tang, Xiong Chen, Dongmei Wang, Ruiping Zhang, Jinlan Zhang,Talanta, 222 (2021) 121500.
A mathematical model-assisted UHPLC-MS/MS method for global profiling and quantification of cholesteryl esters in hyperlipidemic golden hamster. Miao Lin , Zhe Wang , Dongmei Wang, Xiong Chen, Jin-Lan Zhang,Analytical chemistry, 2019, 91,4504–4512.
Strategy for Comprehensive Profiling and Identification of Acidic Glycosphingolipids Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry. Hu T, Jia ZX, Zhang JL., Analytical chemistry, 2017, 89, 7808−7816.
Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Sheng N., Zheng H., Xiao Y., Wang Z., Li ML, zhang JL., Journal of Chromatography A, 2017,1517,97-107.
Quantitative Proteomics and Targeted Fatty Acids Analysis Reveal the Damage of Triptolide in Liver and Kidney. Menglin Li, Ting Hu, Cai Tie, Liang Qu, Hao Zheng, Jinlan Zhang,Proteomics, 2017, DOI: 10.1002/pmic.201700001
Derivatization Strategy for the Comprehensive Characterization of Endogenous Fatty Aldehydes Using HPLC-Multiple Reaction Monitoring. Tie C, Hu T, Jia ZX, Zhang JL. Analytical chemistry, 2016, 88,7762-7768.
Highly Sensitive and Specific Derivatization Strategy to Profile and Quantitate Eicosanoids by UPLC-MS/MS. Hu T, Tie C, Wang Z, Zhang JL. Analytica Chimica Acta, 2017,950,108-118.
Ultraperformance liquid chromatography-tandem mass spectrometry method for profiling ketolic and phenolic sex steroids using an automated injection program combined with diverter valve switch and step analysis. Caihong Wang, Caisheng Wu, Lin Zhang, Jinlan Zhang*. Analytical chemistry, 2016, 88, 7878-7884.
Automatic Identification Approach for High-Performance Liquid Chromatography-Multiple Reaction Monitoring Fatty Acid Global Profiling. Tie, C.*, Hu, T, Jia, Z. X., Zhang, J. L.** Analytical chemistry , 2015, 87, 8181-8185.
Comprehensive two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry for chemical constituents analysis of tripterygium glycosides tablets, Liang Qu, Yao Xiao, Zhixin Jia, Zhe Wang, Caihong Wang, Ting Hu, Caisheng Wu, Jinlan Zhang*. Journal of Chromatography A, 2015,38,1400, 65–73.
Novel identification strategy for ground coffee adulteration based on UPLC-HRMS oligosaccharide profiling. Cai, T.*, Ting, H., Jin-Lan, Z**. Food chemistry 2016, 190, 1046-1049.
Systematic considerations for a multicomponent pharmacokinetic study of Epimedii wushanensis herba: From method establishment to pharmacokinetic marker selection. Caihong Wang#, Caisheng Wu#, Jinlan Zhang*, Ying Jin. Phytomedicine, 2015, 22, 487-97.
Novel strategy for herbal species classification based on UPLC-HRMS oligosaccharide profiling. Tie, C.*, Hu, T., Guo, B., & Zhang, J**. J Pharm Biomed Anal, 2015, 111, 14-20.
Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide, Liang Qu, Feng Qu, Zhixin Jia, Caihong Wang, Caisheng Wu, Jinlan Zhang*. Journal of Ethnopharmacology, 2015,170,28–38.
HPLC-MRM Relative Quantification analysis of Fatty Acids Based on a Novel Derivatization Strategy. Cai Tie, Ting Hu, Xinxiang Zhang, Jiang Zhou, Jinlan Zhang*. Analyst, 2014, 139, 6154-6159.
A new strategy for the discovery of epimedium metabolites using high-performance liquid chromatography with high resolution mass spectrometry,Ying Jin, Cai-Sheng Wu, Jin-Lan Zhang, Ying-Fei Li. Analytica Chimica Acta, 2013, 768, 111– 117.

专著


国家级规划教材《药物分析学》,编委,高等教育出版社,2021年出版
《固相萃取技术与应用》第二版,编委,科学出版社,2019年

专利


发明专利:聚合物型药用辅料组成成分的计算机辅助分析系统及方法,201811240919.2,专利申请人:田润涛,张金兰,高佳敏,王喆等,授权公告日:2021年5月1日。
软件著作权:药用辅料吐温自动鉴别系统,软著登字第3208504号,著作权人:科迈恩(北京)有限公司,公布日期:2018年9月1号。

科技奖励

1998年,获奖名称:藁本的化学研究,主要完成人:于德泉、陈若芸 、谢凤指、丁平羽 、黄彦合、张金兰,获奖类别:中华人民共和国卫生部科学技术进步奖,获奖等级:二等奖。
2018年,获奖名称:中草药成分及其代谢分析新方法和应用,主要完成人:张金兰、吴彩胜、王彩虹、生宁、郑浩、获奖类别:中国分析测试协会科学技术奖,获奖等级:一等奖。