主要从事心脑血管药理学、抗炎免疫药理学及新药研发工作。研究方向包括：脑卒中的靶点发现和机制研究；多靶点脑细胞保护药物开发；靶向中性粒细胞的药物发现；高通量药物筛选及体内外药效学评价。

1. Longrui Wang, Ziyuan Zhao, Zhaowei Li, Yinru Jiang, Wenjing Sun, Guanhua Du, Ruili Shi#, Linglei Kong#. Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke. Acta Pharmacol Sin. 2026;47(3):549-565.
2. Shuang Li, Penghui Yuan, Xinyi Zhang, Meiru Liu, Dezhi Yang#, Linglei Kong#, Li Zhang#, Yang Lu, Guanhua Du. Revolutionizing sepsis therapy: Machine learning-driven co-crystallization reveals emodin's therapeutic potential. Chin Chem Lett. 2026;37(2):111289.
3. Sen Zhang, Chengdi Liu, Wan Li, Yizhi Zhang, Yihui Yang, Hong Yang, Ziyuan Zhao, Fang Xu, Wanxin Cao, Xiaoxue Li, Jinhua Wang#, Linglei Kong#, Guanhua Du#. Kaempferol promotes angiogenesis through HIF-1α/VEGF-A/Notch1 pathway in ischemic stroke rats. Neurochem Int. 2025,185:105953.
4. Chengdi Liu, Sen Zhang, Aiping Wen#, Linglei Kong#, Guanhua Du#. Salvianolic acid A prevented neuroinflammation and apoptosis caused by acute ischemic stroke through inhibiting the HMGB1/NF-κB signaling pathway. Brain Res Bull. 2025,233:111657.
5. Meiru Liu, Yinru Jiang, Penghui Yuan, Shuang Li, Baoxi Zhang, Xia Zhou, Bin Su, Yifei Xie, Dezhi Yang#, Linglei Kong#, Li Zhang#, Yang Lv, Guanhua Du. Crystal engineering optimizes emodin-tetramethylpyrazine combination: From cocrystal design to in vivo anti-colitis efficacy assessment. Int J Pharm X. 2025,10:100436.
6. Ziyuan Zhao, Guangyi Wei, Longrui Wang, Yinru Jiang, Xinyi Zhang, Lianhua Fang#, Guanhua Du#, Linglei Kong#. Pretreatment with Dan-Shen-Yin granules alleviates ethanol-induced gastric mucosal damage in rats by inhibiting oxidative stress and apoptosis via Akt/Nrf2 signaling pathway. Phytomedicine. 2024;132:155866. 7. Ziyuan Zhao, Zirong Pan, Sen Zhang, Guodong Ma, Wen Zhang, Junke Song, Yuehua Wang, Linglei Kong#, Guanhua Du#. Neutrophil extracellular traps: A novel target for the treatment of stroke. Pharmacol Ther. 2023;241:108328.