研究方向主要有防治神经退行性疾病新药、抗病毒感染新药的发现与机制研究，以及药物信息学研究。
职 称：研究员
所属科室：国家药物筛选中心
导师类别：博士生导师
联系方式：Liuailin@imm.ac.cn
所属重点实验室：
1. Zhao J, Guo P, Fang J, Wang C, Yan C, Bai Y, Wang Z, Du G, Liu A*. Neuroinflammation inhibition and neuroprotective effects of purpurin, a potential anti-AD compound, screened via network proximity and gene enrichment analyses. Phytother Res. 2024 Nov;38(11):5474-5489.
2. Zhang B, Zhao J, Yan C, Bai Y, Guo P, Wang C, Wang, Du G, Liu A*. Combination of RNA-seq and proteomics reveals the mechanism of DL0410 treatment in APP/PS1 transgenic mouse model of Alzheimer's disease. Biomedicine & Pharmacotherapy, 2024, August, 177: 116940. https://doi.org/10.1016/j.biopha.2024.116940.
3. Liu A*#, Zhao J#, Huls NJ, Zeller M, Wang L and Li T*. The Structural Basis of DL0410, A Novel Multi-Target Candidate Drug for the Treatment of Alzheimer’s Disease. Crystals 2024, 14(1), 59. https://doi.org/10.3390/cryst14010059.
4. Yang ZH, Liu YJ, Ban WK, Liu HB, Lv LJ, Zhang BY, Liu AL, Hou ZY, Lu J, Chen X, You YY. Pterostilbene alleviated cerebral ischemia/reperfusion-induced blood-brain barrier dysfunction via inhibiting early endothelial cytoskeleton reorganization and late basement membrane degradation. Food Funct. 2023 19;14(18):8291-8308. doi: 10.1039/d3fo02639f.
5. Guo P Zhang B, Zhao J, Wang C, Wang Z, Liu A*, Du G*. Medicine-Food Herbs against Alzheimer’s Disease: A Review of Their Traditional Functional Features, Substance Basis, Clinical Practices and Mechanisms of Action. Molecules, 2022 Jan 28;27(3):901. doi.org/10.3390/molecules27030901.
6. Zhang B, Zhao J, Wang Z, Guo P, Liu A* and Du G*. Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and In Vitro Validation. Front. Pharmacol., 2021 Jul 16:12:709607. doi: 10.3389/fphar.2021.709607.
7. Zhang B, Lian W, Zhao J, Wang Z, Liu A*, Du G*. DL0410 alleviates memory impairment in D-galactose-induced aging rats by suppressing neuroinflammation via TLR4/ MyD88/ NF-κB pathway. Oxidative Medicine and Cellular Longevity, 2021 Oct 4:2021:6521146. https://doi.org/10.1155/2021/6521146.
8. Zhang B, Zhao J, Guo P, Wang Z, Xu L, Liu A*, Du G*. Effects of Naodesheng tablets on amyloid beta-induced dysfunction: A traditional Chinese herbal formula with novel therapeutic potential in Alzheimer's disease revealed by systems pharmacology. Biomed Pharmacother. 2021 Sep;141:111916. doi:10.1016/j.biopha.2021.111916.
9. Zhou W, Lian WW, Yan R, Jia H, Xu LJ, Wang L, Liu AL*, Du GH*. DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss. Acta Pharmacol Sin. 2020, 41(5):599-611.
10. Zhang B, Zhao J, Wang Z, Xu L, Liu A*, Du G*. DL0410 attenuates oxidative stress and neuroinflammation via BDNF/TrkB/ERK/CREB and Nrf2/HO-1 activation. Int Immunopharmacol. 2020 Jul 6;86:106729. doi: 10.1016/j.intimp.2020.106729.
11. Pang X, Zhao Y, Song J, Kang, Wu S, Wang L, Liu A*, Du G*. Pharmacokinetics, excretion and metabolites analysis of DL0410, a dual‑acting cholinesterase inhibitor and histamine‑3 receptor antagonist. Mol Med Rep. 2019, 20: 1103-1112.
12. Pang X, Fu W, Wang J, Kang D, Xu L, Zhao Y, Liu AL*, Du GH*. Identification of estrogen receptor α antagonists from natural products By virtual screening approaches. Oxid Med Cell Longev. 2018, 2018:6040149. doi:10.1155/2018/6040149.
13. Pang X#, Zhang B#, Mu G, Xia J, Xiang Q, Zhao X, Liu A*, Du G*, Cui Y*. Screening of cytochrome P450 3A4 inhibitors via in silico and in vitro approaches. RSC Adv, 2018, 8, 34783-34792.
14. Pang XC, Kang D, Fang JS, Zhao Y, Xu VJ, Lian WW, Liu AL*, Du GH*. Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer’s Disease. Chinese Journal of Natural Medicines, 2018, 16(1): 0053-0062.
15. Wang DM, Feng B, Fu H, Liu AL, Wang L, Du GH, Wu S*. Design, Synthesis, and Biological Evaluation of a New Series of Biphenyl/Bibenzyl Derivatives Functioning as Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase. Molecules, 2017, 22: 172; doi:10.3390.
16. Lian W, Fang J, Xu L, Zhou W, Kang D, Xiong W, Jia H, Liu AL*, Du GH*. DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice. Molecules. 2017, 22(3), 410. pii: E410.
17. Lian W, Jia H, Xu L, Zhou W, Kang D, Liu A*, Du G*. Multi-Protection of DL0410 in Ameliorating Cognitive Defects in D-Galactose Induced Aging Mice. Front Aging Neurosci. 2017, 9:409. doi: 10.3389/fnagi.2017.00409.
18. Pang X, Wang L, Kang D, Zhao Y, Wu S, Liu AL*, Du GH*. Effects of P-Glycoprotein on the Transport of DL0410, a Potential Multifunctional Anti-Alzheimer Agent. Molecules 2017, 22(8): 1246. doi: 10.3390/molecules22081246.