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研究员

黄伟

职 称:研究员

所属科室:药物制剂研究室

导师类别:博士生导师

联系方式:13681293575

所属重点实验室:高钟镐课题组;药物传输技术及新型制剂北京市重点实验室

个人简介

黄伟,男,博士,博士生导师,研究员。2008年毕业于香港中文大学,获博士学位(PhD);曾任香港中文大学医学院研究助理。现任药物制剂研究室副主任,在药物递送载体、新型释药系统和创新制剂研究方面具有坚实基础和丰富经验。已招收博士生1人和硕士生9人;培养毕业硕士生4人,其中1名毕业生获得国家奖学金并荣获“北京市优秀毕业生”称号。作为负责人,主持课题10多项,包括北京市自然科学基金、协和青年科研基金、美国中华医学基金会(CMB)基金项目等。在国内进行了基因递送载体的开拓性研究,率先研制壳聚糖纳米粒基因递送系统。在基因递送载体、纳米释药系统和创新制剂等方面取得重要研究成果,申请专利18项,发表论文50多篇。

研究方向

纳米释药系统
肿瘤靶向制剂
基因递送载体

发表论文


Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs. Wei Huang#, Liqing Chen#, Lin Kang#, Mingji Jin, Ping Sun, Xin Xin, Zhonggao Gao*, You Han Bae. Advanced Drug Delivery Reviews, 2017, 115:82-97.
Effective Oral Delivery of Exenatide-Zn2+ complex through Distal Ileum-Targeted Double Layers Nanocarriers Modified with Deoxycholic Acid and Glycocholic Acid in Diabetes Therapy. YingHan, WeiLiu, Liqing Chen, Xin Xin, Qiming Wang, Xintong Zhang, Mingji Jin, Zhonggao Gao*, Wei Huang*. Biomaterials, 2021: 120944.
Systemic siRNA delivery with a dual pH-responsive and tumor-targeted nanovector for inhibiting tumor growth and spontaneous metastasis in orthotopic murine model of breast carcinoma. Bo Fan, Lin Kang, Liqing Chen, Ping Sun, Mingji Jin, Qiming Wang, You Han Bae, Wei Huang*, Zhonggao Gao*. Theranostics, 2017, 7(2):357-376.
Anti-tumor effects in mice induced by survivin-targeted siRNA delivered through polysaccharide nanoparticles.Feifei Yang#, Wei Huang# , Yunfei Li, Shan Liu, Mingji Jin, Yuli Wang, Lihua Jia, Zhonggao Gao*. Biomaterials, 2013, 34(22):5689-5699.
Recent advances in drug delivery systems for targeting cancer stem cells. Hongxia Duan, Yanhong Liu, Zhonggao Gao, Wei Huang*. Acta Pharmaceutica Sinica B, https://doi.org/10.1016/j.apsb.2020.09.016.
Enhancing anti-melanoma outcomes in mice using novel chitooligosaccharide nanoparticles loaded with therapeutic survivin-targeted siRNA. Xuan Liu, Liqing Chen,YingyingZhang, XinXin, LinglingQi, MingjiJin, Youyan Guan*, ZhonggaoGao*, WeiHuang*. 2021, European Journal of Pharmaceutical Sciences, https://doi.org/10.1016/j.ejps.2020.105641.
Improving anti-tumor outcomes for palliative intratumoral injection therapy through lecithin-chitosan nanoparticles loading paclitaxel-cholesterol complex. Xiao-yang Chu#, Wei Huang#, Yu-li Wang, Ling-wei Meng, Li-qing Chen, Ming-ji Jin, Lu Chen, Chun-hong Gao, Cheng Ge, Zhong-gao Gao*, Chun-sheng Gao*. International Journal of Nanomedicine, 2019, 14:689-705.
Improving glioblastoma therapeutic outcomes via doxorubicin-loaded nanomicelles modified with borneol. Lingwei Meng, Xiaoyang Chu, Haoyue Xing, Xuan Liu, Xin Xin, Liqing Chen, Mingji Jin,Youyan Guan*, Wei Huang*, Zhonggao Gao*.2019, International Journal of Pharmaceutics, 567: 118485.
Improving anti-tumor outcomes for colorectal cancer therapy through in situ thermosensitive gel loading harmine. Zhenzhen Li, Liqing Chen, Chenghui He, Ying Han, Mingfeng Han, Yingying Zhang, Lingling Qi, Wei Huang*, Zhonggao Gao*, Xuezhong Xing*, Jianguo Xing*. American Journal of Translational Research, 2020;12(5):1658-1671.
Smart polymeric nanoparticles with pH-responsive and PEG-detachable properties for co-delivering paclitaxel and survivin siRNA to enhance antitumor outcomes. Mingji Jin, Guangming Jin, Lin Kang, Liqing Chen, Zhonggao Gao*, Wei Huang*. International Journal of Nanomedicine, 2018, 13:2405-2426.
siRNA-loaded poly(histidine-arginine)6-modifed chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis.Ping Sun, Wei Huang*, Lin Kang, Mingji Jin, Bo Fan, Hongyan Jin, Qiming Wang, Zhonggao gao*. International Journal of Nanomedicine, 2017, 12:3221-3234.
Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer.Liqing Chen, Wei Huang*, Zhonggao Gao*, Weishuo Fang, Mingji Jin. International Journal of Nanomedicine, 2016, 11:5457-5472.
Inhibition of murine breast cancer growth and metastasis by survivin-targeted siRNA using disulfide cross-linked linear PEI. Shan Liu#, Wei Huang#, Mingji Jin, Bo Fan, Guimin Xia, Zhonggao Gao*. European Journal of Pharmaceutical Sciences, 2016, 82:171-182.
Optimization of the process variables of tilianin-loaded composite phospholipid liposomes based on response surface-central composite design and pharmacokinetic study.Cheng Zeng, Wen Jiang, Meie Tan, Xiaoyi Yang, Chenghui He, Wei Huang*, Jianguo Xing*. European Journal of Pharmaceutical Sciences, 2016, 85:123-131.
Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading aziditaxel as a novel taxane derivative.Li-qing Chen#, Zhe-ming Zhang#, Wei Huang*, Zhong-gao Gao*, Wei-shuo Fang, Ming-ji Jin, Lian Yu. Pharmazie, 2017, 72(3):152-160.
Development of solid lipid nanoparticles containing total flavonoid extract from Dracocephalum moldavica L. and their therapeutic effect against myocardial ischemia-reperfusion injury in rats.Mei-e Tan, Cheng-hui He, Wen Jiang, Cheng Zeng, Ning Yu, Wei Huang*, Zhong-gao Gao, Jian-guo Xing*. International Journal of Nanomedicine, 2017, 12:3253-3265.
Enhancing in vivo bioavailability in beagle bogs of GLM-7 as a novel anti-leukemia drug through a self-emulsifying drug delivery system for oral delivery.Yuli Wang#, Ning Yu#, Rui Guo#, Meiyan Yang, Li Shan, Wei Huang*,Wei Gong, Shuai Shao, Xiaoping Chen, Chunsheng Gao*. Current Drug Delivery, 2016, 13:131-142.
Novel ethylcellulose-coated pellets for controlled release of metoprolol succinate without lag phase: characterization, optimization and in vivo evaluation. Yuli Wang, Jiahui Yang, Yong Qian, Meiyan Yang, Yan Qiu, Wei Huang*, Li Shan, Chunsheng Gao*. Drug Development and Industrial Pharmacy, 2015, 41(7):1120-1129.
Simultaneous Determination of Six Active Compounds in Yixin Badiranjibuya Granules, a Traditional Chinese Medicine, by RP-HPLC-UV Method.Ning Yu, ChenHui He, Gulistan Awuti, Cheng Zeng, JianGuo Xing*, Wei Huang*. Journal of Analytical Methods in Chemistry, 2015:974039.
The influence of the gut microbiota on the bioavailability of oral drugs.Xintong Zhang, Ying Han, Wei Huang, Mingji Jin, Zhonggao Gao. Acta Pharmaceutica Sinica B, In press, https://doi.org/10.1016/j.apsb.2020.09.013
Improved Antitumor Outcomes for Colon Cancer Using Nanomicelles Loaded with the Novel Antitumor Agent LA67.Minhu Cui, Mingji Jin, Mingfeng Han, Yingda Zang, Chuangjun Li, Dongming Zhang, Wei Huang, Zhonggao Gao*, Xuezhe Yin*. International Journal of Nanomedicine, 2020, 15:3563-3576.
Anti-tumor outcome evaluation against non-small cell lung cancer in vitro and in vivo using PolyI:C as nucleic acid therapeutic agent. Yedan Wu, Wei Huang, Liqing Chen, Mingji Jin, Zhonggao Gao*, Changshan An*, Haixiang Lin.American Journal of Translational Research, 2019, 11(4): 1919-1937.
Improving the anti-keloid outcomes through liposomes loading paclitaxel–cholesterol complexes. Mengjiao Wang, Liqing Chen, Wei Huang, Mingji Jin, Qiming Wang, Zhonggao Gao*, Zhehu Jin*. International Journal of Nanomedicine, 2019,14:1385-1400.
Topical application of JAK1/JAK2 inhibitor momelotinib exhibits significant anti-Inflammatory responses in DNCB-induced atopic dermatitis model mice.Wenyu Jin, Wei Huang, Liqing Chen, Mingji Jin, Qiming Wang, Zhonggao Gao*, Zhehu Jin*. International Journal of Molecular Sciences, 2018, 19(12), 3973.
Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma. Qiming Wang, Zhonggao Gao*, Shan Liu, Bo Fan, Lin Kang, Wei Huang, Mingji Jin. Biomaterials, 2014, 35(25):7008-7021.

专著

专利


一种包载生物大分子药物的口服纳米聚合物靶向递送系统. 高钟镐; 韩颖; 黄伟; 陈丽青. 2019-9-27, 中国发明专利, 201910927139.3.
一种磷脂-聚乙二醇-狂犬病毒衍生肽聚合物,其制备方法及应用. 黄伟; 高钟镐; 韩明峰; 张哲明; 陈丽青. 2018-7-25, 中国发明专利, 201810833188.6.
一种磷脂-聚乙二醇-冰片聚合物,其制备方法及应用. 黄伟; 高钟镐; 孟令玮; 陈丽青. 2018-6-21, 中国发明专利, 201810641691.1
一种狂犬病毒糖蛋白衍生肽修饰的脑靶向核酸递送载体及其应用.黄伟; 高钟镐; 张哲明. 2017-4-25, 中国发明专利, ZL201810317197.X
一种聚乙烯亚胺-b-聚乳酸嵌段共聚物、其制备方法及应用. 高钟镐; 金明姬; 黄伟. 2017-10-27, 中国发明专利, 201711023906.5.
一种治疗阿尔茨海默病的缓释制剂及其制备方法. 王晓良, 高钟镐, 黄伟, 王琰, 黄海洪, 彭英, 辛欣, 郭芳, 冯茹.2017-4-24,中国发明专利, ZL2017102685878
还原敏感性聚乙烯亚胺衍生物,其制备方法及应用. 高钟镐; 柳珊; 黄伟; 杨飞飞; 金明姬. 2015-9-30, 中国发明专利, ZL201410112675.5.
一种可以载药或给药、加快药物溶出的功能性吸管装置. 吴松, 黄伟, 刘璇, 陈丽青, 李天磊, 杨庆云, 张驰, 戚燕, 韩遵圣, 张文轩. 2018-6-21,中国实用新型专利, ZL201820957252.7.
一种用于儿童或老人口服给药的功能性给药装置.吴松, 黄伟, 刘璇, 李天磊, 张驰, 杨庆云, 戚燕, 韩遵圣, 张文轩. 2018-12-10, 中国实用新型专利, ZL201822058956.3.
一种用于给药或载药的功能性吸管. 吴松, 高钟镐, 黄伟, 刘璇, 陈丽青, 李天磊, 杨庆云, 张驰, 戚燕, 韩遵圣, 张文轩. 2018-12-10, 中国实用新型专利, ZL201822058834.4.
一种用于给药专用吸管的止回阀. 黄伟, 吴松, 高钟镐, 刘璇, 陈丽青, 李天磊. 2018-10-25, 中国实用新型专利, ZL201821728700.2.

科技奖励


2014,“第七批中央和国家机关、中央企业优秀援疆干部人才”个人二等功,
黄伟, 中共新疆维吾尔自治区委员会、新疆维吾尔自治区人民政府.
2010, 2010年度中国医学科学院药物研究所“梁周黄于刘青年科技奖”三等奖, 黄伟, 杨飞飞, 吕明, 高钟镐, 中国医学科学院药物研究所.
2013, “第十一届全国医药卫生青年科技论坛”药物组三等奖,黄伟,杨飞飞,高钟镐, 李云飞, 柳珊, 金明姬, 邢建国, 何承辉, 国家卫生和计划生育委员会科技教育司、中国医学科学院.
2012, 《药学学报》第六届优秀研究论文,黄伟, 吕明, 高钟镐, 金明姬, 杨长青, 《药学学报》编辑部.