1. 活性天然产物的靶向挖掘、全合成与结构修饰
2. 基于天然产物的创新药物研发

1. Ji-Ping Liao#, Ji-Chao Zhou#, Ying-Li Fan#, Jian-Shuang Jiang, Xu Zhang, Xiang Yuan, Pei-Cheng Zhang*, Xiao-Wei Zhang*, Ya-Nan Yang*, Discovery and biomimetic synthesis of the first stilbenolignan-stilbene hybrids from Heterosmilax yunnanensis inhibiting myocardial fibroblast activation, Chinese Chemical Letters, doi: https://doi.org/10.1016/j.cclet.2025.112295
2. Jiping Liao#, Xinnan Li#, Cheng Fan#, Xiang Yuan, Peicheng Zhang*, Dongmei Wang*, Ying Peng*, and Yanan Yang*, Discovery of a Natural Small-Molecule Inhibitor to Novel Target STAT5A for Ischemic Stroke Therapy, Journal of Medicinal Chemistry, 2025, 68, 22799-22817.
3. Ji-Ping Liao#, Jiang Li#, Wen-Jie Qin, Xiu-Mei Duan, Peng-Fei Wang, Jin-Ying Tian, Xiang Yuan, Pei-Cheng Zhang, Fei Ye, Ya-Nan Yang*, Two racemic pairs of benzo bicyclo[3.3.1]/[4.2.1] nonene stilbenoid dimers from Heterosmilax yunnanensis and structural revision of syagrusin A, Chinese Chemical Letters, 2025, 36, 110687.
4. Gangsheng Li, Xiang Yuan, Fu Liu, Zhihua Liu, Xujie Wang, Yuanyuan Liu, Yanmin Chen, Tingting Wang, Yanan Yang*, Peicheng Zhang*, Three-step synthesis of flavanostilbenes with a 2-cyclohepten-1-one core by Cu-mediated [5 + 2] cycloaddition/decarboxylation cascade, Chinese Chemical Letters, 2025, 36, 109880.
5. Jichao Zhou#, Yuanyuan Liu#, Xiaoli Wei#, Meng Yuan#, Xu Zhang#, Lingfeng Qin, Bing Cui, Pingping Li, Jing Zhang, Ziming Feng, Jianshuang Jiang, Xiang Yuan, Ruibing Xu, Zhimeng Zhang, Peicheng Zhang*, Xiaowei Zhang*, Yanan Yang*, Glycnsisitin A: A promising bicyclic peptide against heart failure that facilitates TFRC-mediated uptake of iron in cardiomyocytes, Acta Pharmaceutica Sinica B, 2024, 14, 3125-3139.
6. Zhenyuan Li#, Shuying Li#, Zeyu Xing#, Quanchang Gu, Rongrong Du, Jianshuang Jiang, Xiang Yuan, Xu Zhang, Xiaoguang Chen, Nina Xue, Peicheng Zhang*, Jing Jin*, Yanan Yang*, Discovery of Natural Ah Receptor Antagonists from Salvia miltiorrhiza Bunge and Synthesis of Analogs for Tumor Immunotherapy, Journal of Medicinal Chemistry, 2024, 67, 1243-1261.
7. Linghao Zhao, Haiwei Yan, Jianshuang Jiang, Xu Zhang, Xiang Yuan, Yanan Yang*, Peicheng Zhang*, Effective assignment of positional isomers in dimeric shikonin and its analogs by 1H NMR Spectroscopy. Chinese Chemical Letters, 2024, 35, 108863.
8. Rongrong Du#, Ruoyu Wang#, Jichao Zhou#, Huanhuan Gao, Wenjie Qin, Xiumei Duan, Yanan Yang*, Xiaowei Zhang*, Peicheng Zhang*, Heteryunine A, an amidated tryptophan-catechin-spiroketal hybrid with antifibrotic activity from Heterosmilax yunnanensis. Bioorganic Chemistry, 2024, 151, 107618.
9. Ling-Feng Qin#, Huan-Huan Gao#, Xu Zhang, Xiang Yuan, Zi-Ming Feng, Pei-Cheng Zhang, Jian-Shuang Jiang*, Ya-Nan Yang*, Seventeen undescribed iridoid derivatives with anti-inflammatory effects from Hedyotis diffusa and their structure-activity relationships, Phytochemistry, 2024, 217, 113904.
10. Huan-Huan Gao#, Ling-Feng Qin#, Xu Zhang, Xiang Yuan, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang*, Ya-Nan Yang*, Six new iridoid glycosides from the whole plants of Hedyotis diffusa, Journal of Asian Natural Products Research, 2024, 26, 112–119.
11. Jian-Shuang Jiang#, Quan-chang Gu#, Zi-Ming Feng, Xiang Yuan, Xu Zhang, Pei-Cheng Zhang*, Ya-Nan Yang*, The tanshinones from the plant of Salvia miltiorrhiza, Phytochemistry, 2023, 210, 113673.
12. Quan-Chang Gu#, Xiao-Li Wei#, Qing Ji#, Zi-Ming Feng, Jian-Shuang Jiang, Xu Zhang, Xiang Yuan, Xiao-Wei Zhang*, Pei-Cheng Zhang*, Ya-Nan Yang*, Two dimers generated by lithospermic decarboxylation coupling from Danshen, Bioorganic Chemistry, 2022, 128, 106065.
13. Jian-Shuang Jiang#, Quan-chang Gu#, Zi-Ming Feng, Xiang Yuan, Xu Zhang, Pei-Cheng Zhang*, Ya-Nan Yang*, The phenolic acids from the plant of Salvia miltiorrhiza, Fitoterapia, 2022, 159, 105180.
14. Ya-Nan Yang, Bing Han, Peng-Fei Yang, Zi-Ming Feng, Jian-Shuang Jiang and Pei-Cheng Zhang*, A concise approach for determining the relative configuration of H-7 and H-8 in 8,4′-oxyneolignans by 1H NMR spectroscopy, Organic Chemistry Frontiers, 2019, 6, 886–891.
15. Xujie Wang#, Fu Liu#, Juping Yun, Ziming Feng, Jianshuang Jiang, Yanan Yang*, and Peicheng Zhang*, Iron-Catalyzed Synthesis of the Hexahydrocyclopenta[c]furan Core and Concise Total Synthesis of Polyflavanostilbene B. Angewandte Chemie International Edition, 2018, 57, 10127–10131.