目前主要研究领域为肿瘤药理学和急慢性肾脏病药理学。利用现代药理学的新思路和新方法，结合大数据分析和AI新算法，从生物数据库中预测同疾病相关核酸靶点和蛋白靶点。同时，利用分子生物学的方法，验证靶点的有效性，并筛选有效治疗药物。重点研究方向包括：
1. 线粒体自噬、内质网应激同肾脏疾病的相关性。
2. 脓毒症相关急性肾损伤的治疗。
3. 脂代谢同慢性肾病和多发性骨髓瘤的相关性；
4. 天然产物治疗急慢性肾脏损伤的药物筛选。

1. Xinyue Tao, Xikun Liu, Qi Wang, Sujuan Wang, Clarence T.T. Wong, Zhiling Ma, Yi Zhou, Wenying Shi, Xiaoying Zhang, *, Pengcheng Lin, *, Sen Zhang* , Oenothein B inhibits CD47 and PD-L1 expression via PI3K/AKT/NF-κB/HIF‑1α signaling pathway in B16‑F10 melanoma cells, Food sciences and human wellness, DOI: 10.26599/FSHW.2025.9250774.
2. Ting Wang, Xiufeng Liao, Xiaodi Zhao, Kai Chen, Yangzhonghui Chen, Hui Wen, Dali Yin, Yuchen Wang, Bin Lin, Sen Zhang, Huaqing Cui, Rational design of 2-benzylsulfinyl-benzoxazoles as potent and selective indoleamine 2, 3-dioxygenase 1 inhibitors to combat inflammation, Bioorganic Chemistry, 2024, 152, 107740.
3. Ying-Da Zang, Hai-Jie Wu, Xin-Yi Chen, Zhi-ling Ma, Chuang-Jun Li, Jie Ma, Xiao-Guang Chen, Li Sheng,* Sen Zhang* and Dong-Ming Zhang* Synthesis and Biological Evaluation of Novel Psidium Meroterpenoid Derivatives Against Cisplatin-induced Acute Kidney Injury, Journal of Medicinal Chemistry, 2024, 67(16), 14234-14255.
4. Wenying Shi, Zhaojun Li, Weida Wang, Xikun Liu, Haijie Wu, Xiaoguang Chen, Xunrong Zhou, Sen Zhang，Dynamic gut microbiome-metabolome in c-BSA induced experimental immune-complex glomerulonephritis and effect of losartan and MMF on microbiota modulation, Journal of Pharmaceutical Analysis, 2024, 14(4):100931.
5.Yuanyuan Chen, Xikun Liu, Jie Ma, Weida Wang, Zhaojun Li, Haijie Wu, Zhanxi Lu, Dongming Zhang, Xiaoying Zhang, Yu Zhang, Sen Zhang, Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ. Journal of ethnopharmacology, 2024, (329): 118156.
6. Zhaojun Li, Xingguang Zhang, Haijie Wu, Zhiling Ma, Xikun Liu, Jie Ma, Dongming Zhang, Li Sheng, Xiaoguang Chen and Sen Zhang, Hydrangea paniculata coumarins attenuate experimental membranous nephritis by bidirectional interactions with the gut microbiota, Communications Biology, 2023, 6, 1189.
7. Xiaohu Shi, Zhaojun Li, Weifeng Lin, Wenying Shi, Rongrong Hu, Gang Chen, Xuemei Li, Xuewang Li, Sen Zhang. Altered intestinal microbial flora and metabolism in patients with idiopathic membranous nephropathy. American Journal of Nephrology. 2023, 54(11-12):451-470.
8. Weida Wang, Li Sheng, Yuanyuan Chen, Zhaojun Li, Haijie Wu, Jie Ma, Dongming Zhang, Xiaoguang Chen*, Sen Zhang*. Total coumarin derivates from Hydrangea paniculata attenuate renal injuries in cationized-BSA induced membranous nephropathy by inhibiting complement activation and interleukin 10-mediated interstitial fibrosis, phytomedicine, 2022;96:153886. (IF:7.9)
9. Yuanyuan Chen, Xiaoguang Chen*, Sen Zhang*, Druggability of lipid metabolism modulation against renal fibrosis. Acta Pharmacologica Sinica, 2022, 43(3):505-519.
10. Meng Jin, Li Kong, Ying Han, Sen Zhang*. Gut microbiota enhances the chemosensitivity of hepatocellular carcinoma to 5-fluorouracil in vivo by increasing curcumin bioavailability. phytotherapy research, 2021, 35(10):5823-5837. DOI:10.1002/ptr.7240. IF:6.388（11次）
11. Long non-coding RNAs: from disease code to drug role. Yuanyuan Chen, Zhaojun Li, Xiaoguang Chen, Sen Zhang*, Acta Pharmaceutica Sinica B, 2021, 11(2), 340-354.
12. Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis. Zhang Sen, Wang Weida, Ma Jie, Sheng Li, Zhang Dongming, Chen Xiaoguang*, Phytomedicine, 2019,57, 385-395.