药用植物来源的活性天然物质的挖掘、生物合成、结构优化和异源生产
1. 基于整合组学的活性天然产物的功能基因元件挖掘和生物功能鉴定
2. 基于计算机模拟和量子化学计算的生物酶催化机制阐明和功能设计改造
3. 基于多元底盘的活性天然产物的合成生物学研究

1. Yujiao Li; Yiting Mei; Mark Schmidt-Dannert; Yaxin Lv; Reuben J. Peters; Meirong Jia; The Pursuit of a Hydroxylation Switch Uncovers a Key Residue for Various Product Outcomes in the ent-Kaurene Synthase from Bradyrhizobium japonicum, Organic Letters,2025, 27, 3942−3946
2. Xin Sun; Haobin Zhang; Yuping Jia; Jingyi Li; Meirong Jia; CRISPR-Cas9-based genome-editing technologies in engineering bacteria for the production of plant-derived terpenoids. Engineering Microbiology, 2024,10015
3. Yiting Mei; Miaomiao Liang; Jingyi Li; Meirong Jia; Transcriptome-based mining and functional characterization of class II diterpene synthases from Isodon eriocalyx. Chinese Medical Biotechnology, 2024, 19(3):206-213
4. Andrew Muchlinski; Meirong Jia; Kira Tiedge; Jason S. Fell; Kyle A. Pelot; Lisl Chew; Danielle Davisson; Yuxuan Chen; Justin Siegel; John T. Lovell; Philipp Zerbe; Cytochrome P450-catalyzed biosynthesis of furanoditerpenoids in the bioenergy crop switchgrass (Panicum virgatum L.), The Plant Journal, 2021, 108:1053-1068
5. Meirong Jia; Jasmonic acid transport in wound-induced systemic immunity, Molecular Plant, 2020, 13:1673 Editor’s highlight
6. Meirong Jia; Yue Zhang; Justin B. Siegel; Dean J. Tantillo; Reuben J. Peters; Switching on a nontraditional enzymatic base–deprotonation by serine in the ent-kaurene synthase from Bradyrhizobium japonicum, ACS Catalysis, 2019, 9:8867-8871
7. Meirong Jia; Sambit K. Mishra; Samuel Tufts; Robert L. Jernigan; Reuben J. Peters; Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases, Metabolic Engineering, 2019, 55:44-58
8. Meirong Jia; Terrence E. O’Brien; Yue Zhang; Justin B. Siegel; Dean J. Tantillo; Reuben J. Peters; Changing face: A key residue for the addition of water by sclareol synthase, ACS Catalysis, 2018, 8:3133-3137
9. Meirong Jia; Ke Zhou; Samuel Tufts; Samuel Schulte; Reuben J. Peters; A pair of residues that interactively affect diterpene synthase product outcome, ACS Chemical Biology, 2017, 12(3):862-867
10. Meirong Jia; Kevin C. Potter; Reuben J. Peters; Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis, Metabolic Engineering, 2016, 37:24-34