EN

科研队伍

您现在的位置: 首页> 科研队伍> 研究员

研究员

胡宽

职 称:研究员

所属科室:天然药物活性物质与功能国家重点实验室

导师类别:博士生导师

联系方式:010-50927211;hukuan@imm.ac.cn

所属重点实验室:天然药物活性物质与功能国家重点实验室

研究方向

本实验室以临床问题为导向,聚焦癌症、心脑血管等重大疾病,开发:
1、诊疗核药和硼中子俘获治疗药物;
2、活性多肽发现和进化平台技术;
3、新型核素标记方法;
4、面向未来的量子生命和医学技术。

发表论文

1. Q. Zuo et al., Triazination/IEDDA Cascade Modular Strategy Installing Pyridines/Pyrimidines onto Tyrosine Enables Peptide Screening and Optimization. Journal of the American Chemical Society 147, 9576-9589 (2025).
2. S. Zhang et al., Radiopharmaceuticals and their applications in medicine. Signal Transduction and Targeted Therapy 10, 1 (2025).
3. S. Zhang et al., Enhanced radiotheranostic targeting of integrin α5β1 with PEGylation-enabled peptide multidisplay platform (PEGibody): A strategy for prolonged tumor retention with fast blood clearance. Acta Pharmaceutica Sinica B 15, 692-706 (2025).
4. J. Ma et al., Discovery of a highly specific radiolabeled antibody targeting B-cell maturation antigen: Applications in PET imaging of multiple myeloma. European Journal of Nuclear Medicine and Molecular Imaging 52, 599-610 (2025).
5. N. Cheng et al., Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia-Reperfusion Injury. Advanced Science n/a, 2410590 (2025).
6. D. Wang et al., Environmentally responsive hydrogel promotes vascular normalization to enhance STING anti-tumor immunity. Journal of Controlled Release 372, 403-416 (2024).
7. Z. He et al., Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment. Nat Nanotechnol 19, 1386-1398 (2024).
8. L. Xie et al., A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy. Cell Reports Medicine 4, 100960 (2023).
9. Z. Xiao et al., PEIGel: A biocompatible and injectable scaffold with innate immune adjuvanticity for synergized local immunotherapy. Materials Today Bio 15, 100297 (2022).
10. D. Wang et al., A multifunctional nanotheranostic agent potentiates erlotinib to EGFR wild-type non-small cell lung cancer. Bioactive Materials 13, 312-323 (2022).
11. D. Wang et al., Therapeutic hydrogel for enhanced immunotherapy: A powerful combination of MnO2 nanosheets and vascular disruption. Nano Today 47, 101673 (2022).
12. J. Sun et al., Imaging-guided targeted radionuclide tumor therapy: From concept to clinical translation. Advanced Drug Delivery Reviews 190, 114538 (2022).
13. K. Hu et al., Whole-body PET tracking of a d-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors. Acta Pharmaceutica Sinica B 12, 1363-1376 (2022).
14. L. Xie et al., Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy. Journal for ImmunoTherapy of Cancer 9, e002616 (2021).
15. C. Wang et al., Customization of Conductive Elastomer Based on PVA/PEI for Stretchable Sensors. Small 16, 1904758 (2020).
16. K. Hu et al., Boron agents for neutron capture therapy. Coordination Chemistry Reviews 405, 213139 (2020).
17. K. Hu et al., Self-Assembly of Constrained Cyclic Peptides Controlled by Ring Size. CCS Chemistry 2, 42-51 (2020).
18. K. Hu et al., Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy. Nature communications 11, 2778 (2020).
19. H. Wang et al., Black Phosphorus Nanosheets Passivation Using a Tripeptide. Small 14, 1801701 (2018).
20. K. Hu et al., Tuning peptide self-assembly by an in-tether chiral center. Science Advances 4, eaar5907 (2018).
21. K. Hu et al., An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide. Angewandte Chemie International Edition 55, 8013-8017 (2016).